福建省单中心器官捐献转化率和器官产出率及其影响因素研究

Analysis of conversion rate, organ procurement rate and influencing factors of organ donation: a single-center study in Fujian province

目的探讨福建省单中心器官捐献转化率和器官产出率及其影响因素。方法回顾性分析2018年11月至2021年6月福建医科大学附属协和医院182例潜在器官捐献者的基本信息,分析器官捐献转化率、器官捐献成功者的基本情况及器官捐献失败者捐献失败的原因。分析器官捐献产出情况及器官捐献数量的影响因素。结果182例潜在器官捐献者中,捐献成功46例,捐献转化率为25.3%;失败136例,失败原因包括家属不同意(58.1%)、无充足时间评估(24.3%)和未达到捐献状态标准(17.6%)。46例器官捐献者共捐献大器官和组织212个,包括肾脏88个、肝脏42个、肺脏15个、心脏19个和角膜48个,人均捐献大器官和组织4.6个,人均捐献大器官3.6个。年龄、性别、籍贯、捐献辖区和血型是大器官捐献数量的影响因素;捐献辖区是组织捐献数量的影响因素。结论福建省单中心器官捐献转化率偏低,家属不同意是最主要的原因。应针对性地选择合适的潜在器官捐献者开展器官捐献工作,提升器官捐献转化率和器官产出率。

Objective To investigate the conversion rate,organ procurement rate and influencing factors of organ donation in a single center from Fujian province.Methods Baseline data of 182 potential organ donors of Fujian Medical University Union Hospital from November 2018 to June 2021 were retrospectively analyzed.The conversion rate of organ donation,baseline data of successful organ donors and the causes of failure of organ donors were identified.The organ procurement rate and the influencing factors of the number of organ donations were analyzed.Results Among 182 potential organ donors,46 cases were successful organ donors with a conversion rate of 25.3%.In addition,136 cases failed to donate organ.The main causes included disagreement from family members(58.1%),insufficient evaluation time(24.3%)and ineligible for donation criteria(17.6%).A total of 212 large organs and tissues were donated by 46 organ donors,including 88 kidneys,42 livers,15 lungs,19 hearts and 48 corneas,with 4.6 large organs and tissues,and 3.6 large organs for each donor.Age,sex,native place,organ donation area and blood type were the influencing factors of the number of large organ donations.Organ donation area was the influencing factor of the number of tissue donations.Conclusions The conversion rate of organ donation is relatively low in a single center from Fujian province.Disagreement from family members is the main cause.Suitable potential organ donors should be selected for organ donation to improve the conversion rate and organ procurement rate of organ donation.