左舒必利及抑酸药物治疗胃反流性食管炎的疗效及其胃蛋白酶影响

Effect of Levosulpiride and Antacid on Gastric Reflux Esophagitis and Pepsin Level

目的探究左舒必利联合抑酸药物在治疗胃反流性食管炎中的效果及对患者胃蛋白酶的影响。方法将82例胃反流性食管炎患者依据随机数字表法分为观察组和对照组各41例,对照组接受抑酸药物治疗,观察组在对照组基础上加用左舒必利进行治疗,均治疗4周,对比两组治疗有效率、治疗前后食管动力学指标、胃蛋白酶(PG)指标、炎症因子水平,并对治疗前、治疗2周及治疗4周GerdQ评分进行对比,最后评估治疗不良反应发生率。结果①观察组治疗有效率95.12%,高于对照组的78.05%(P<0.05);②治疗后观察组食管括约肌压力较对照组大,卧位反流时间百分比、立位反流时间百分比小于对照组(P<0.05);③治疗后PGⅠ、PGⅡ水平出现上升,同时观察组上述指标均高于对照组(P<0.05);④治疗后第2周及第4周观察组患者GerdQ评分低于对照组(P<0.05);⑤治疗后IL-10、IL-1β均下降,同时观察组上述指标均低于对照组(P<0.05);⑥不良反应发生率对比差异无统计学意义(P>0.05);结论左舒必利联合抑酸药物对胃反流性食管炎具有较好的治疗效果,能够改善患者食管动力学,缓解其炎性状态,提高胃蛋白酶水平,同时治疗安全性较高。

Objective To explore the effect of levosulpiride combined with antacid in the treatment of gastric reflux esophagitis and pepsin level of patients.Methods 82 patients with gastric reflux esophagitis were divided into control group(received antacid)and experimental group(received antacid and levosulpiride),41 cases each,randomly.The treatment time was 4 weeks.The effective rate,esophageal dynamic index,pepsin(PG)index and inflammatory factor level before and after treatment were compared between the two groups;the GerdQ scores before treatment,2 weeks and 4 weeks treatment were compared;incidence of adverse reactions in 2 groups were evaluated.Results①The effective rate of experimental group(95.12%)was higher than that of control group(78.05%)(P<0.05);②After treatment,the esophageal sphincter pressure in the experimental group was greater than that in the control group.The percentage of flow time and the percentage of standing reflux time in the experimental group were smaller than that in the control group(P<0.05);③The levels of PGⅠand PGⅡincreased after treatment,and the above indexes in the observation group were higher than those in the control group(P<0.05);④The GerdQ score of the observation group was lower than that of the control group at the 2 and 4 weeks after treatment(P<0.05);⑤After treatment,IL-10 and IL-1βin the two groups all decreased,and their levels in the observation group were lower than those in the control group(P<0.05);⑥There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Levocapril combined with antacid has a good therapeutic effect on gastric reflux esophagitis,which could improve patients’state,improve the level of pepsin,and have less side effects.