小儿定喘口服液联合重组人干扰素α1b治疗儿童毛细支气管炎的效果及对FeNO、气道炎症反应的影响

Effect of Xiao’er Dingchuan Oral Liquid Combined with Recombinant Human Interferon α1b on Bronchiolitis in Children and Its Effect on FeNO and Airway Inflammatory Response

目的:探讨小儿定喘口服液联合重组人干扰素α1b治疗儿童毛细支气管炎的效果及对呼出气一氧化氮(FeNO)、气道炎症反应的影响。方法:将我院儿科2019年1月—2020年12月收治的61例儿童毛细支气管炎患儿随机分为联合组31例和对照组30例,对照组予以重组人干扰素α1b治疗,联合组在对照组基础上予以小儿定喘口服液联合治疗,比较两组治疗有效率、恢复情况、FeNO水平以及气道炎症反应[降钙素原(PCT)、单核细胞趋化蛋白1(MCP-1)、白细胞介素6(IL-6)、γ干扰素(IFN-γ)]。结果:联合组治疗有效率高于对照组(P<0.05);联合组患儿咳嗽、肺部啰音、喘息和发热消退时间均短于对照组(P<0.05);联合组FeNO水平低于对照组(P<0.05);联合组PCT、MCP-1及IL-6水平低于对照组,IFN-γ水平高于对照组(P<0.05)。结论:小儿定喘口服液联合重组人干扰素α1b治疗儿童毛细支气管炎能够提高治疗有效率,加快患儿康复,降低患儿FeNO水平,减轻患儿炎症反应。

Objective:To investigate the effect of Xiao’er Dingchuan oral liquid combined with recombinant human interferonα1 b on bronchiolitis in children and its effect on exhaled nitric oxide(FeNO)and airway inflammation.Methods:A total of 61 children with bronchiolitis admitted to the pediatric department of our hospital from January 2019 to December 2020 were randomly divided into the combined group(31 cases)and the control group(30 cases).The control group was treated with recombinant human interferonα1 b,and the combined group was treated with Xiao’er Dingchuan oral liquid on the basis of the control group.The effective rate,recovery,FeNO level and airway inflammatory response were compared between the two groups[procalcitonin(PCT),monocyte chemoattractant protein 1(MCP-1),interleukin 6(IL-6),and interferonγ(IFN-γ)].Results:The effective rate of the combined group was higher than that of the control group(P<0.05).The cough,pulmonary rales,wheezing and fever subsided time in the combined group were shorter than those in the control group(P<0.05).FeNO level in the combined group was lower than that in the control group(P<0.05);the levels of PCT,MCP-1 and IL-6 in the combined group were lower than those in the control group,and the level of IFN-γwas higher than that in the control group(P<0.05).Conclusion:TXiao’er Dingchuan oral liquid combined with recombinant human interferonα1 b in the treatment of bronchiolitis in children can improve the treatment efficiency,accelerate the rehabilitation of children,reduce the level of FeNO in children,and reduce the inflammatory response of children.