中药远志的研究进展

Research progress on Polygalae Radix

中药远志药用历史悠久,传统功效为安神益智,交通心肾,祛痰,消肿,现代临床上主要用于治疗健忘、失眠、心神不安等。现代研究结果表明,远志中主要含有三萜皂苷、口山酮、寡糖酯类成分,具有改善记忆、抗痴呆、脑保护、镇静催眠、镇咳祛痰等活性。该文综述了近三十年来远志化学成分、药理作用、质量控制、代谢4个方面的研究进展,以期为远志的深入研究开发提供依据。

Polygalae Radix has long been used in China for calming the mind,promoting intelligence,communicating the heart and kidney,eliminating phlegm,and reducing swelling.At present,it is used to treat amnesia,insomnia,and malaise.Modern research has revealed that Polygalae Radix mainly contains triterpenoid saponins,xanthone,oligosaccharide esters,etc.,with the activities of improving memory,resisting dementia,protecting the brain,relieving cough,and removing phlegm,as well as sedation and hypnosis.The present study reviews the research progress on chemical composition,pharmacological action,quality control,and metabolism of Polygalae Radix in the past 30 years,to provide a theoretical basis for further research and development.