摘要
为了研究厚皮香八角Illicium ternstroemioides茎枝中的seco-prezizaane型倍半萜类成分,采用硅胶柱色谱、ODS柱色谱及半制备型HPLC等方法,从海南厚皮香八角茎枝的95%乙醇提取物中分离得到了6个化合物,根据波谱数据解析和文献对比,分别鉴定为burmanicumolide D(1)、veranisatin A(2)、veranisatin B(3)、dihydroconiferylalcohol(4)、pinoresinol(5)、(-)-matairesinol(6)。其中化合物1为新的seco-prezizaane型倍半萜内酯,化合物2~6为首次从该植物中分离得到。肿瘤细胞毒性(A549、HepG2、HGC27、MCF7、HCT-116)、抗柯萨奇病毒B3以及抗流感病毒(H3N2)活性测试显示,化合物1~6均未发现明显的活性。
Three seco-prezizaane-type sesquiterpene lactones,one phenylpropanoid,and two lignans were isolated from the 95%ethanol extract of stems and branches of Illicium ternstroemioides with silica gel column chromatography,ODS column chromatography,and preparative HPLC.Based on the spectral data,they were identified as burmanicumolide D(1),veranisatin A(2),veranisatin B(3),dihydroconiferylalcohol(4),pinoresinol(5),(-)-matairesinol(6),respectively.Among them,compound 1 was a new secoprezizaane-type sesquiterpene lactone,and 2-6 were obtained from this plant for the first time.None of these compounds display antiviral or cytotoxic activities.
作者
张建培
李文睿
雍锦瑶
杨佳
马双刚
ZHANG Jian-pei;LI Wen-rui;YONG Jin-yao;YANG Jia;MA Shuang-gang(Institute of Materia Medica,Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China)
出处
《中国中药杂志》
CAS
CSCD
北大核心
2021年第22期5848-5852,共5页
China Journal of Chinese Materia Medica
基金
国家自然科学基金面上项目(22177135,21672261)。