血管内皮标志物在脓毒症诊断和预后评估中的研究进展

Research progress of endothelial biomarkers in sepsis diagnosis and prognosis evaluation

脓毒症是指机体对感染的反应失调,继而出现危及宿主生命的器官功能障碍的临床综合征。尽管现在越来越提倡脓毒症早期治疗,但其发病率和病死率仍然很高。脓毒症和脓毒性休克的早期识别与评估至关重要。基于此,目前有许多生物标志物和筛选系统被研发。内皮细胞是覆盖在血管内表面重要成分,其在器官形成、组织稳态和免疫应答中起着重要作用。内皮细胞的过度持续激活和损伤导致的血管高通透性是脓毒症发生的重要机制。血液中各种内皮相关生物标志物可用于脓毒症的早期诊断和预后评估。本文将对内皮生物标志物与脓毒症诊断和预后评估的相关文献进行总结,评估临床应用的价值。

Sepsis is a clinical syndrome defined as life-threatening organ dysfunction caused by a dysregulated host response to infection.Despite appropriate early management,the mortality and morbidity rates remain high now.Early identification and diagnosis of sepsis and septic shock are vitally important.For this reason,many biomarkers and screening systems have been investigated.Endothelium covering the inner surface of blood vessels plays an important role in the organogenesis,tissue homeostasis and immune response.Excessive activation and damage of the endothelial cells resulting in hyperpermeability of the vessels are crucial mechanisms of sepsis.Various endothelium-related biomarkers in blood could be utilized in the early diagnosis and prognosis of sepsis.In the present review,we summarized the literatures on endothelial biomarkers that have been used in sepsis diagnosis and prognosis evaluation in order to evaluate their clinical values.