蛇毒血凝酶联合云南白药治疗非静脉曲张上消化道出血的临床效果

Clinical effect of Snake Venom Hemagglutinase combined with Yunnan Baiyao in the treatment of non-varicose upper gastrointestinal bleeding

目的探讨蛇毒血凝酶联合云南白药治疗非静脉曲张上消化道出血的临床效果。方法选取2020年4月至2021年2月长江大学附属仙桃市第一人民医院收治的68例非静脉曲张上消化道出血患者作为研究对象,采用随机数字表法分为对照组(34例)与治疗组(34例),对照组使用云南白药进行治疗,治疗组在对照组的基础上加用蛇毒血凝酶进行治疗。比较两组的血清指标[血清皮质醇水平、高敏C-反应蛋白(hs-CRP)]、治疗总有效率和并发症总发生率。结果治疗组治疗总有效率、血清指标优于对照组,差异有统计学意义(P<0.05),两组并发症总发生率比较,差异无统计学意义(P>0.05)。结论在治疗非静脉曲张上消化道出血中采用云南白药与蛇毒血凝酶联合疗效较理想,不良反应未增加,在临床使用中值得借鉴。

Objective To investigate the clinical effect of Snake Venom Hemagglutinase combined with Yunnan Baiyao in the treatment of non-varicose upper gastrointestinal bleeding.Methods A total of 68 patients with non-varicose upper gastrointestinal bleeding admitted to Xiantao First People′s Hospital affiliated to Yangtze University from April 2020 to February 2021 were selected as the research subjects.The patients were divided into control group(34 cases)and treatment group(34 cases)by random number table method.The control group was treated with Yunnan Baiyao.The treatment group was treated with Snake Venom Hemagglutinase on the basis of the control group.Serum indicators(serum cortisol levels,high-sensitive C-reactive protein[hs-CRP]),total response rate and total incidence of complications were compared between the two groups.Results The total effective rate and serum indexes in the treatment group were better than those in the control group,and the differences were statistically significant(P<0.05).There was no statistically significant difference in the total incidence of complications between the two groups(P>0.05).Conclusion The combination of Yunnan Baiyao and Snake Venom Hemagglutinase in the treatment of non-varicose upper digestive tract bleeding has an ideal efficacy and low adverse reactions,which is worth reference in clinical use.