地高辛注射液在心力衰竭合并快速型房颤患者中的临床应用

Clinical application of Digoxin Injection in patients with heart failure and rapid atrial fibrillation

目的比较在常规治疗基础上应用地高辛注射液与西地兰治疗心力衰竭合并快速型房颤患者的疗效。方法选取2020年1月至2021年3月南华大学附属第三医院的100例心力衰竭合并快速型房颤的患者作为研究对象,按照随机数字表法分为实验组和对照组,每组各50例。所有患者均接受常规抗心力衰竭治疗,试验组使用地高辛注射液,对照组使用西地兰注射液进行治疗,比较两组患者心力衰竭治疗疗效、治疗前后心室率、N末端B型利钠肽原(NT-proBNP)、肌酐值及肾小球滤过率。结果试验组的治疗总有效率高于对照组,差异有统计学意义(P<0.05);两组治疗后各时间点的心室率整体比较,差异有统计学意义(P<0.05),试验组治疗3、6 h后的心室率低于对照组,差异有统计学意义(P<0.05);两组治疗9、12、15、18、21、24 h后的心室率比较,差异无统计学意义(P>0.05)。两组治疗前的肌酐值及肾小球滤过率水平比较,差异无统计学意义(P>0.05)。治疗后,两组的NT-proBNP均低于治疗前,且试验组的NT-proBNP低于对照组,差异有统计学意义(P<0.05)。结论地高辛注射液能有效改善心力衰竭合并房颤患者的症状,控制心室率,总体耐受性良好,在该类患者的治疗中具有重大的临床价值。

Objective To observe the efficacy of Digoxin Injection and Cedi-lanid in the treatment of patients with heart failure and rapid atrial fibrillation on the basis of conventional treatment.Methods A total of 100 patients with heart failure and rapid atrial fibrillation in the Third Affiliated Hospital of South China University from January 2020 to March 2021were selected as the research objects,and they were divided into the experimental group and the control group according to random number table method,with 50 cases in each group.All patients received conventional anti-heart failure treatment,the experimental group was given Digoxin injection,the control group was given Cedi-lanid Injection for treatment.The therapeutic effect of heart failure,ventricular rate,N-terminal B-type natriuretic peptide(NT-proBNP),creatinine value and glomerular filtration rate were compared between the two groups before and after treatment.Results The total effective rate of the experimental group was higher than that of the control group,and the difference was statistically significant(P<0.05).The overall comparison of ventricular rate at each time point after treatment between the two groups was statistically significant(P<0.05).The ventricular rate in the experimental group was lower than that in the control group 3 and 6 h after treatment,the difference was statistically significant(P<0.05).There was no significant difference in ventricular rate between the two groups at 9,12,15,18,21,24 h after treatment(P>0.05).There were no significant differences in creatinine and glomerular filtration rate between the two groups before treatment(P>0.05).After treatment,the NT-proBNP of the two groups were lower than before treatment,and the NT-proBNP of the experimental group was lower than the control group,the differences were statistically significant(P<0.05).Conclusion Digoxin Injection can effectively improve the symptoms of patients with heart failure and atrial fibrillation,control the ventricular rate,and is well tolerated.It has great clinical value in the treatment of such patients.