舍曲林联合家庭治疗青少年抑郁障碍的临床研究

Clinical study of Sertraline combined with family therapy for adolescent depression disorder

目的探讨舍曲林联合家庭治疗青少年抑郁障碍的临床效果。方法选取2020年1月至10月吉安市第三人民医院收治的80例青少年抑郁障碍患者作为研究对象,采用数字奇偶法将其分为联合组和单一组,每组各40例。联合组患者采用舍曲林+家庭治疗方式干预,单一组患者采用舍曲林药物干预。比较两组患者的简易应对方式问卷(SCSQ)评分、汉密顿抑郁量表(HAMD)评分。结果治疗前,联合组患者的积极应对方式评分[(1.75±0.61)分]、消极应对方式评分[(2.70±0.56)分]与单一组[(1.77±0.63)、(2.75±0.57)分]比较,差异无统计学意义(P>0.05);治疗后,联合组患者的积极应对方式评分[(2.25±0.45)分]高于单一组[(1.95±0.53)分],消极应对方式评分[(1.85±0.61)分]低于单一组[(2.71±0.43)分],差异有统计学意义(P<0.05)。治疗前,联合组患者的HAMD评分[(25.49±2.29)分]与单一组[(25.53±2.32)分]比较,差异无统计学意义(P>0.05);治疗后,联合组患者的HAMD评分[(8.52±1.11)分]低于单一组[(13.45±1.99)分],差异有统计学意义(P<0.05)。结论舍曲林+家庭治疗方式联合运用,可显著改善青少年抑郁障碍患者的积极应对方式以及消极应对方式,改善抑郁。

Objective To explore the clinical effect of Sertraline combined with family therapy on adolescent patients with depression.Methods Eighty adolescent patients with depression who were admitted to the Third People′s Hospital of Ji′an City from January 2020 to October 2020 were selected as the research objects.They were divided into the joint group and the single group by numerical odd-even method,with 40 cases in each group.Patients in the combined group were treated with Sertraline+family therapy,and patients in the single group were treated with Sertraline.Summary coping style questionnaire(SCSQ)score and Hamilton depression scale(HAMD)score were compared between the two groups.Results Before treatment,there were no statistically significant differences in positive coping style score and negative coping style score between the combined group([1.75±0.61],[2.70±0.56]points)and the single group([1.77±0.63],[2.75±0.57]points)(P>0.05).After treatment,the positive coping style score of the combined group([2.25±0.45]points)was higher than that of the single group([1.95±0.53]points),and the negative coping style score([1.85±0.61]points)was lower than that of the single group([2.71±0.43]points),the differences were statistically significant(P<0.05).Before treatment,there was no statistically significant difference in HAMD score between the combined group([25.49±2.29]points)and the single group([25.53±2.32]points)(P>0.05).After treatment,the HAMD score of the combined group([8.52±1.11]points)was lower than that of the single group([13.45±1.99]points),and the difference was statistically significant(P<0.05).Conclusion The combination of Sertraline and family therapy can significantly improve the positive coping style and negative coping style of adolescent depressive disorder patients,and improve depression.