金银花汤联合大剂量土茯苓对梅毒患者外周血淋巴细胞以及血清白介素因子的影响研究

Research on the Effect of Honeysuckle Decoction Combined with Large Dosage of Poria Cocos on Peripheral Lymphocytes and Serum Interleukin Factor in Syphilis Patients

目的探讨金银花汤联合大剂量土茯苓对梅毒患者外周血淋巴细胞以及血清白介素因子的影响研究。方法选取2019年1月—2020年6月在沈阳市第六人民医院就诊的50例梅毒患者,按照随机数字表法分成对照组和试验组,每组25例。对照组予以常规治疗,试验组在常规治疗的基础上使用金银花汤联合大剂量土茯苓,比较患者外周血内T淋巴细胞及血清白介素因子水平。结果试验组患者治疗后Th1以及Th1/Th2指标高于对照组患者,Th2指标低于对照组患者,差异有统计学意义(P<0.05),试验组患者治疗后患者IL-2、IL-8、IL-10指标低于对照组患者,差异有统计学意义(P<0.05)。结论对梅毒患者,采取金银花汤联合大剂量土茯苓治疗的临床效果显著,有效地改善了外周血淋巴细胞和血清白介素因子含量。

Objective To investigate the effect of honeysuckle decoction on peripheral lymphocytes and serum interleukin-factor of syphilis patients.Methods From January 2019 to June 2020 in Shenyang Sixth People’s Hospital,50 syphilis patients were divided into control group and experimental group according to random number table method,with 25 cases in each group.The control group was given conventional treatment,the experimental group was given honeysuckle decoction combined with large dose of Poria cocos on the basis of conventional treatment,and the levels of T lymphocytes in peripheral blood and serum interleukin factor were compared.Results After treatment,Th1 and Th1/Th2 indexes in the experimental group were higher than those in the control group,and Th2 indexes were lower than those in the control group,and the difference had statistically significant differences(P<0.05).IL-2,IL-8 and IL-10 indexes in the experimental group were lower than those in the control group,and the difference had statistically significant differences(P<0.05).Conclusion In the treatment of syphilis,honeysuckle decoction combined with large dose of poria cotta has significant clinical effect,and can effectively improve the content of peripheral blood lymphocytes and serum interleukin-factor.