理脾安肠汤治疗肠易激综合征临床观察

Clinical observation on Lipi Anchang Decoction in the Treatment of Irritable Bowel Syndrome

目的观察理脾安肠汤治疗肠易激综合征患者的临床效果。方法选择2018年1月—2019年12月北京中医药大学东直门医院通州院区脾胃病科门诊153例肠易激综合征患者随机分为治疗组78例(口服中药理脾安肠汤)和对照组75例(口服马来酸曲美布汀胶囊),观察2组治疗前后的症状、药物不良反应及复发率,评价2组的总体症状疗效和中医证候疗效。结果治疗前2组总体症状评分差异无统计学意义(P>0.05),具有可比性,治疗期间对照组3例出现不良反应,治疗组无不良反应发生;2组治疗后总体症状评分均较治疗前显著降低(P<0.01),治疗组(72.56±41.71)分显著低于对照组(137.58±42.45)分(P<0.01);治疗组中医证候疗效总有效率92.31%(72/78)显著高于对照组79.17%(57/72)(P<0.01);治疗组复发率21.79%(17/78)明显低于对照组41.67%(30/72)(P<0.01)。结论理脾安肠汤治疗肠易激综合征,可显著提高患者总体症状疗效和中医证候疗效,不良反应少,复发率低。

Objective To observe the clinical effect of Lipi Anchang decoction on patients with irritable bowel syndrome.Methods 153 patients with irritable bowel syndrome were randomly divided into treatment group of 78 cases(was treated with traditional Chinese medicine Lipi Anchang decoction)and control group 76 of cases(was treated with trimebutine maleate capsule),the symptom changes before and after treatment,adverse drug reactions and recurrence rate in the two groups was observed.The overall symptom efficacy and TCM syndrome efficacy of the two groups was evaluated.Results There was no significant difference in overall symptom scores between the two groups before treatment(P>0.05),Adverse reactions occurred in 4 cases of control group during treatment,there was no adverse reaction in the treatment group.After treatment,the overall symptom scores of both groups decreased significantly compared with those before treatment(P<0.01),The treatment group(72.56±41.71)was significantly lower than the control group(137.58±42.45)(P<0.01).The total effective rate of TCM syndromes in the treatment group(92.31%,72/78)was significantly higher than that in the control group(79.17%,57/72)(P<0.01).The recurrence rate of 21.79%(17/78)in the treatment group was significantly lower than 41.67%(30/72)in the control group(P<0.01).Conclusion Treatment of irritable bowel syndrome with Lipi Anchang decoction can significantly improve the overall symptom curative effect and TCM syndrome curative effect of patients,less adverse reactions and low recurrence rate.