中心复合设计法优化聚异丁烯丁二酸酐的制备工艺

Optimization of Preparation Process of Polyisobutylene Succinic Anhydride by Central Composite Design

以聚异丁烯丁二酸酐的酸值为评价指标,采用中心复合设计法对高活性聚异丁烯(PIB)和马来酸酐(MA)热加合制备聚异丁烯丁二酸酐的工艺进行了优化。研究结果表明,反应温度(X_(1))和反应时间(X_(3))对评价指标有非常显著的影响(P<0.01),物料配比(X_(2))对评价指标有显著影响(P<0.1),而搅拌速率(X_(4))对评价指标无显著影响(P>0.1)。拟合所得多元二次方程为Y=78.84+7.83X_(1)+3.02X_(2)+4.87X_(3)-17.55X_(1)^(2)+0.087X_(1)X_(2)+0.81X_(1)X_(3)-3.64X_(2)^(2)+0.34X_(2)X_(3)-3.29X_(3)^(2),相关系数R^(2)=0.955。当选定高活性聚异丁烯(PIB1000),搅拌速率固定在350 r/min时,制备聚异丁烯丁二酸酐的优化工艺为:反应温度为207℃,反应物配比n(MA/PIB)为2.4,反应时间为8.5 h,该工艺得到的聚异丁烯丁二酸酐的酸值为83.9 mgKOH/g。通过验证实验表明,本优化方程具有良好的预测性。

Taking the acid value of polyisobutylene succinic anhydride as an evaluation index,the process of preparing polyisobutylene succinic anhydride by thermal addition of highly active polyisobutylene(PIB)and maleic anhydride(MA)was optimized by using a central composite design method.The research results show that the reaction temperature(X_(1))and reaction time(X_(3))have a very significant impact on the evaluation index(P<0.01),the material ratio(X_(2))has a significant impact on the evaluation index(P<0.1),and the stirring rate(X_(4))has no significant effect on the evaluation index(P>0.1).The fitted multivariate quadratic equation is Y=78.84+7.83X_(1)+3.02X_(2)+4.87X_(3)-17.55X_(1)^(2)+0.087X_(1)X_(2)+0.81X_(1)X_(3)-3.64X_(2)^(2)+0.34X_(2)X_(3)-3.29X_(3)^(2).The correlation coefficient R^(2)=0.955.When the high activity polyisobutylene(PIB1000)is selected and the stirring rate is fixed at 350 r/min,the optimized process for preparing polyisobutylene succinic anhydride is as follows:the reaction temperature is 207℃,the reactant ratio n(MA/PIB)is 2.4,the reaction time is 8.5 h,and the acid value of the polyisobutylene succinic anhydride obtained by this process is 83.9 mgKOH/g.The verification experiment shows that the optimization equation has good predictability.