lncRNA UCA1和miRNAs在消化系统肿瘤中的作用机制研究进展

Research progress of the action mechanism of lncRNA UCA1 and miRNAs in digestive system tumors

消化系统肿瘤的发病率和死亡率呈逐年增长趋势,严重威胁着人类的生命健康。近年来研究发现,尿路上皮癌胚抗原1(UCA1)是一种长链非编码RNA(lncRNA),在胃癌、结直肠癌及食管癌等多种消化系统肿瘤组织或细胞中的表达明显升高,且可通过与miRNAs相互调控而影响肿瘤细胞的增殖、迁移、侵袭、上皮-间质转化、凋亡及耐药等过程。该文综述lncRNA UCA1与miRNAs在胃癌、结直肠癌及食管癌等消化系统肿瘤中的作用机制研究进展,并展望lncRNA UCA1作为新的生物标志物及治疗靶点的应用前景。

The incidence and mortality rate of digestive system tumors showed an increasing trend year by year,which seriously threatens human life and health.Recent years,studies have found that urothelial carcinoma embryonic antigen 1(UCA1)is a long non-coding RNA(lncRNA),its expression significantly increased in a variety of digestive system tumor tissues or cells such as gastric cancer,colorectal cancer and esophageal cancer.In addition,UCA1 can interact with miRNAs to affect the proliferation,migration,invasion,epithelial-to-mesenchymal transition(EMT),apoptosis and drug resistance of tumor cells.The research progress of the action mechanism of lncRNA UCA1 and miRNAs in digestive system tumors(including gastric cancer,colorectal cancer and esophageal cancer)is reviewed,and the application of lncRNA UCA1 as a new biomarker and therapeutic target is prospected in present paper.