改良硬化治疗方案在Le,g型食管胃静脉曲张破裂出血中的临床效果与安全性研究

Clinical Efficacy and Safety of Modified Sclerotherapy in Le, g Type Esophagogastric Variceal Hemorrhage

目的:探讨改良硬化治疗方案在Le,g型食管胃静脉曲张破裂出血中的临床效果与安全性。方法:选择常州市第三人民医院2018年1月-2020年7月治疗的136例Le,g型食管胃静脉曲张破裂出血患者作为研究对象,随机分为对照组和观察组,每组68例。对照组予以常规食管静脉曲张硬化治疗,观察组予以改良硬化治疗。比较两组止血成功率、总住院天数、总医疗费用、曲张静脉有效率、曲张静脉消失率、并发症发生情况及治疗后3、6个月的再出血率。结果:观察组止血成功率高于对照组,总住院天数短于对照组,总医疗费用少于对照组,差异均有统计学意义(P<0.05);观察组曲张静脉有效率、消失率均高于对照组,差异均有统计学意义(P<0.05);观察组并发症发生率(7.35%)低于对照组(20.59%),差异有统计学意义(P<0.05);所有患者均获得随访,观察组治疗后3、6个月的再出血率均低于对照组,差异有统计学意义(P<0.05)。结论:改良硬化治疗方案对Le,g型食管胃静脉曲张破裂出血的效果明显,安全性较高,值得临床推广应用。

Objective:To investigate the clinical effect and safety of modified sclerotherapy in the treatment of Le,g type esophagogastric variceal hemorrhage.Method:A total of 136 patients with Le,g type esophagogastric variceal hemorrhage treated in Changzhou Third People’ Hospital from January 2018 to July 2020 were selected as the research subjects and randomly divided into control group and observation group,68 cases in each group.The control group was treated with conventional esophageal variceal sclerotherapy,and the observation group was treated with modified sclerotherapy.The success rate of hemostasis,total days of hospitalization,total medical expenses,effective rate of varicose vein,disappearance rate of varicose vein,the incidence of complications and the rate of rebleeding at 3 and 6 months after treatment were compared between the two groups.Result:The success rate of hemostasis in the observation group was higher than that in the control group,the total hospitalization days were shorter than that in the control group,and the total medical expenses were lower than that in the control group,the differences were statistically significant (P<0.05);the effective rate and varicose vein disappearance rate of observation group were higher than those of control group,the differences were statistical significance (P<0.05);the complication rate of the observation group (7.35%) was lower than that of the control group (20.59%),and the difference was statistically significant (P<0.05).All patients were followed up,and the rate of rebleeding at 3 and 6 months after treatment in the observation group were lower than those in the control group,the differences were statistical significance (P<0.05).Conclusion:Modified sclerotherapy has obvious effect on Le,g type esophagogastric varices hemorrhage,with high safety,and is worthy of clinical application.