血清GDF-15、CXCL12与老年慢性阻塞性肺疾病急性加重期的相关性研究

Study on the Correlation between Serum GDF-15, CXCL12 and the Acute Exacerbation of Elderly Patients with Chronic Obstructive Pulmonary Disease

目的:探讨血清GDF-15、CXCL12与老年慢性阻塞性肺疾病急性加重期的相关性研究。方法:选取2020年1-9月本院125例老年COPD患者,根据疾病情况分为AECOPD组(n=64)和稳定期COPD组(n=61);另选取同期60例健康体检者为对照组。比较三组血清GDF-15和CXCL12水平和肺功能指标(FEV_(1)%pred、FEV_(1)/FVC%)。分析血清GDF-15和CXCL12水平与肺功能的相关性,采用ROC曲线评估血清GDF-15和CXCL12对患者的诊断价值。结果:三组血清GDF-15和CXCL12水平比较,差异均有统计学意义(P<0.05)。AECOPD组与稳定期COPD组的血清GDF-15、CXCL12水平均高于对照组,AECOPD组均高于稳定期COPD组,差异均有统计学意义(P<0.05)。三组FEV_(1)%pred、FEV_(1)/FVC%比较,差异均有统计学意义(P<0.05),AECOPD组与稳定期COPD组中FEV_(1)%pred、FEV_(1)/FVC%均低于对照组,AECOPD组FEV_(1)%pred、FEV_(1)/FVC%均低于稳定期COPD组,差异均有统计学意义(P<0.05)。Pearson相关性分析显示,血清GDF-15和CXCL12水平与FEV_(1)%pred、FEV_(1)/FVC%呈负相关(P<0.05)。血清中GDF-15诊断AECOPD的ROC曲线下面积(AUC)为0.741,CXCL12的AUC为0.731。结论:GDF-15和CXCL12水平可作为COPD急性加重和恶化的预测指标,值得推广。

Objective:To explore the correlation between serum GDF-15,CXCL12 and the acute exacerbation of elderly patients with chronic obstructive pulmonary disease.Method:A total of 125 elderly patients with COPD in our hospital from January to September 2020 were selected,they were divided into AECOPD group (n=64) and stable COPD group (n=61) according to disease conditions,another 60 healthy subjects were selected as the control group.Serum GDF-15 and CXCL12 levels and lung function indexes (FEV_(1)% pred,FEV_(1)/FVC%) were compared among three groups.The correlation between serum GDF-15 and CXCL12 levels and lung function was analyzed,and the diagnostic value of serum GDF-15 and CXCL12 for patients was evaluated by ROC curve.Result:There were statistically significant differences in serum GDF-15 and CXCL12 levels among three groups (P<0.05).Serum GDF-15 and CXCL12 levels in the AECOPD group and stable COPD group were higher than those in control group,and those in the AECOPD group were higher than those in the stable COPD group,the differences were statistically significant (P<0.05).There were statistically significant differences in FEV_(1)%/pred,FEV_(1)/FVC% among there groups (P<0.05).The FEV_(1)% pred and FEV_(1)/FVC% in the AECOPD group and stable COPD group were lower than those in the control group,FEV_(1)% pred and FEV_(1)/FVC% in the AECOPD group were lower than those in the stable COPD group,the differences were statistically significant (P<0.05).Pearson correlation analysis showed that serum GDF-15 and CXCL12 levels were negatively correlated with FEV_(1)% pred and FEV_(1)/FVC% (P<0.05).The area under ROC curve (AUC) of GDF-15 in serum for AECOPD diagnosis was 0.741,and that of CXCL12 was 0.731.Conclusion:GDF-15 and CXCL12 levels can be used as predictors of acute exacerbation and exacerbation of COPD,which are worthy of promotion.