子痫前期孕妇血清Hcy、Cys C、UmAlb、VEGF、PLGF水平及其与病情严重程度的相关性

Serum Hcy,Cys C,UmAlb,VEGF,PLGF Levels in Pregnant Women with Preeclampsia and Their Correlation with the Severty of Illness

目的:了解子痫前期(PE)孕妇血清中同型半胱氨酸(Hcy)、胱抑素C(Cys C)、尿微量白蛋白(UmAlb)、血管内皮生长因子(VEGF)及胎盘生长因子(PLGF)水平表达情况,并探讨其与PE病情严重程度的相关性。方法:选择2019年3月-2020年12月在深圳市龙华区人民医院妇产中心就诊并确诊为PE孕妇87例作为PE组,120例健康孕妇作为对照组。分别检测血清中Hcy、Cys C、UmAlb、VEGF及PLGF水平,并对结果进行统计分析。结果:PE组血清Hcy、Cys C、UmAlb及VEGF水平分别为(15.06±4.79)μmol/L、(1.42±0.38)mg/L、(17.20±5.13)mg/L及(6.12±1.30)pg/ml,明显高于对照组的(8.37±2.51)μmol/L、(0.74±0.25)mg/L、(3.04±0.82)mg/L、(2.68±0.75)pg/ml,而PLGF水平为(128.13±35.27)pg/ml,明显低于对照组的(260.52±59.04)pg/ml,差异有统计学意义(P<0.05)。重度PE组血清Hcy、Cys C、UmAlb及VEGF水平分别为(18.06±5.93)μmol/L、(1.85±0.52)mg/L、(27.19±8.36)mg/L及(8.79±1.64)pg/ml,明显高于轻度PE组的(12.62±3.25)μmol/L、(1.07±0.31)mg/L、(9.08±2.57)mg/L、(3.95±1.02)pg/ml,而PLGF水平为(64.89±15.34)pg/ml,明显低于轻度PE组的(179.51±42.68)pg/ml,差异有统计学意义(P<0.05)。经Spearman相关性分析,PE组孕妇血清中Hcy、Cys C、UmAlb及VEGF水平与病情严重程度呈正相关,而PLGF水平呈负相关(P<0.05)。结论:PE孕妇血清中Hcy、Cys C、UmAlb及VEGF水平明显升高,而PLGF水平明显降低,且与病情严重程度有关,可能与PE的发生和发展有密切关系。

Objective:To investigate the levels of serum homocysteine(Hcy),cystatin C(Cys C),urinary microalbumin(UmAlb),vascular endothelial growth factor(VEGF)and placental growth factor(PLGF)in pregnant women with preeclampsia(PE),and to explore their correlation with severty of PE.Method:A total of 87 pregnant women diagnosed with PE who visited the Obstetrics and Gynecology Center of Shenzhen Longhua District People’s Hospital from March 2019 to December 2020 were selected as the PE group,and 120 healthy pregnant women were selected as the control group.Serum levels of Hcy,Cys C,UmAlb,VEGF and PLGF were detected,and the results were analyzed statistically.Result:The serum levels of Hcy,Cys C,UmAlb and VEGF in PE group were(15.06±4.79)μmol/L,(1.42±0.38)mg/L,(17.20±5.13)mg/L and(6.12±1.30)pg/ml,respectively,significantly higher than(8.37±2.51)μmol/L,(0.74±0.25)mg/L,(3.04±0.82)mg/L,(2.68±0.75)pg/ml of the control group,while the level of PLGF was(128.13±35.27)pg/ml,significantly lower than(260.52±59.04)pg/ml of the control group,the differences were statistically significant(P<0.05).Serum levels of Hcy,Cys C,UmAlb and VEGF in severe PE group were(18.06±5.93)μmol/L,(1.85±0.52)mg/L,(27.19±8.36)mg/L and(8.79±1.64)pg/ml,respectively,significantly higher than(12.62±3.25)μmol/L,(1.07±0.31)mg/L,(9.08±2.57)mg/L,(3.95±1.02)pg/ml in mild PE group,while the level of PLGF was(64.89±15.34)pg/ml,which was significantly lower than(179.51±42.68)pg/ml in mild PE group,and the differences were statistically significant(P<0.05).Spearman correlation analysis showed that serum levels of Hcy,Cys C,UmAlb and VEGF in PE group were positively correlated with the severity of disease,while PLGF level was negatively correlated(P<0.05).Conclusion:The serum levels of Hcy,Cys C,UmAlb and VEGF in pregnant women with PE are significantly increased,while the level of PLGF is significantly decreased,which is related to the severity of the disease,and may be closely related to the occurrence and development of PE.