氯吡格雷联合依折麦布治疗冠心病心绞痛效果及其对内皮功能的影响

Efficacy of Clopidogrel Combined with Ezetimibe in the Treatment of Coronary Heart Disease and Angina Pectoris and Its Effect on Endothelial Function

目的:探究氯吡格雷联合依折麦布治疗冠心病心绞痛效果及其对内皮功能的影响。方法:回顾性分析普宁市人民医院2019年3月-2020年12月收治的80例冠心病心绞痛患者的临床资料。根据有无依折麦布与氯吡格雷联用分为对照组(n=38)与观察组(n=42)。两组均给予常规药物基础治疗,对照组给予依折麦布,观察组在对照组的基础上给予氯吡格雷,两组均治疗4周。观察两组患者心绞痛和心电图疗效,比较治疗前后两组患者心绞痛发作频率、持续时间、缓解心绞痛所需硝酸甘油剂量,一氧化氮(NO)、内皮素(ET)及血栓素B_(2)(TXB_(2))水平。结果:治疗后,观察组的心绞痛和心电图疗效总有效率均高于对照组(P<0.05);治疗前两组心绞痛发作频率、持续时间、缓解心绞痛所需硝酸甘油剂量比较差异均无统计学意义(P>0.05),治疗后两组心绞痛发作频率、持续时间、缓解心绞痛所需硝酸甘油剂量均下降,且观察组的心绞痛发作频率,缓解心绞痛所需硝酸甘油均少于对照组,心绞痛持续时间短于对照组(P<0.05);两组治疗前ET、TXB_(2)、NO水平比较差异均无统计学意义(P>0.05),治疗后观察组NO水平高于对照组,ET、TXB_(2)水平均低于对照组(P<0.05)。结论:氯吡格雷联合依折麦布治疗冠心病心绞痛患者可以提高临床效果,减轻患者临床症状,改善患者血管内皮功能。

Objective:To explore the effect of Clopidogrel combined with Etzemab on coronary heart disease and angina pectoris and its effect on endothelial function.Method:Clinical data of 80 patients with coronary heart disease and angina pectoris admitted to Puning City People’s Hospital from March 2019 to December 2020 were retrospectively analyzed.They were divided into control group(n=38)and observation group(n=42)according to whether Ezetimibe and Clopidogrel were used together.Both groups were given conventional drug basic treatment,the control group was given Ezetimibe,observation group was given Clopidogrel on the basis of control group,both groups were treated for 4 weeks.The effect of angina pectoris and electrocardiogram in the two groups were observed,the angina pectoris attack frequency,angina pectoris duration,relief angina pectoris need Nitroglycerin dose,the levels of nitric oxide(NO),endothelin(ET),and thromboxane B_(2)(TXB_(2))before and after the treatment of the two groups of patients were compared.Result:After treatment,the total effective rate of angina pectoris and electrocardiogram curative in the observation group were higer than those of the control group(P<0.05);there were no significant differences between the two groups in the angina pectoris attacks frequency,angina pectoris duration,and relief angina pectoris need Nitroglycerin dose(P>0.05).After treatment,the angina attacks frequency,angina attacks duration and relief angina pectoris need Nitroglycerin dose decreased in both groups,and the angina attacks frequency and relief angina pectoris need Nitroglycerin dose in the observation group were less than those in the control group,and the angina attacks duration was shorter than that in the control group(P<0.05).There were no significant differences in the levels of ET,TXB_(2)and NO between the two groups before treatment(P>0.05).After treatment,the level of NO in the observation group was higher than that in the control group,while the levels of ET and TXB_(2)were lower than those in the control group(P<0.05).Conclusion:Clopidogrel combined with Etzemab in the treatment of coronary heart disease and angina pectoris can improve the clinical efficacy,alleviate the clinical symptoms and improve the vascular endothelial function of patients.