泮托拉唑对胃溃疡患者胃黏膜修复指标及胃肠激素的影响观察

Effect of Pantoprazole on Gastric Mucosal Repair Index and Gastrointestinal Hormones in Patients with Gastric Ulcer

目的:探讨泮托拉唑对胃溃疡患者胃黏膜修复指标及胃肠激素的影响,以期为临床治疗提供参考依据。方法:选取2017年10月-2020年12月淄博市张店区妇幼保健院收治的100例胃溃疡患者,根据就诊先后顺序分为对照组和观察组,每组50例。对照组采用阿莫西林、克拉霉素和奥美拉唑治疗,观察组采用阿莫西林、克拉霉素及泮托拉唑治疗。比较两组疗效、不良反应发生情况;比较两组治疗前后的GAS、MTL、CCK水平及胃溃疡边缘黏膜的VEGF、EGF和COX-2水平。结果:观察组总有效率为94.00%,高于对照组的80.00%,差异有统计学意义(P<0.05)。治疗前,两组GAS、MTL及CCK水平比较,差异均无统计学意义(P>0.05);治疗后,两组GAS、MTL及CCK水平均低于治疗前,且观察组均低于对照组,差异均有统计学意义(P<0.05)。治疗前,两组VEGF、EGF、COX-2水平比较,差异均无统计学意义(P>0.05);治疗后,两组VEGF、EGF、COX-2水平均高于治疗前,且观察组均高于对照组,差异均有统计学意义(P<0.05)。两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:泮托拉唑联合阿莫西林、克拉霉素治疗胃溃疡可以有效提高临床总有效率,促进溃疡面愈合,有利于胃黏膜的进一步修复,安全可靠,应用价值高。

Objective:To investigate effect of Pantoprazole on gastric mucosal repair and gastrointestinal hormones in patients with gastric ulcer.Method:A total of 100 patients with gastric ulcer admitted to Zibo Zhangdian Maternal and Child Health Hospital from October 2017 to December 2020 were selected,they were divided into control group and observation group according to the order of visit,50 cases in each group.The control group was treated with Amoxicillin,Clarithromycin and Omeprazole,while the observation group was treated with Amoxicillin,Clarithromycin and Pantoprazole.The efficacy and adverse reactions were compared between two groups;the levels of GAS,MTL,CCK and VEGF,EGF and COX-2 of gastric mucosal repair indexes before and after treatment were compared between two groups.Result:The total effective rate of the observation group was 94.00%,which was higher than 80.00%of the control group,the difference was statistically significant(P<0.05).Before treatment,there were no significant differences in GAS,MTL and CCK levels between two groups(P>0.05);after treatment,the levels of GAS,MTL and CCK of both groups were lower than those before treatment,and those of the observation group were lower than those of the control group,the differences were statistically significant(P<0.05).Before treatment,there were no significant differences in VEGF,EGF and COX-2 levels between two groups(P>0.05);after treatment,the levels of VEGF,EGF and COX-2 of both groups were higher than those before treatment,and those of the observation group were higher than those of the control group,the differences were statistically significant(P<0.05).There was no significant difference in the rate of adverse reactions between two groups(P>0.05).Conclusion:Pantoprazole combined with Amoxicillin and Clarithromycin in the treatment of gastric ulcer can effectively improve the total clinical effective rate,promote the healing of ulcer surface,and facilitate the further repair of gastric mucosa,which is safe and reliable and has high application value.