宫颈上皮内瘤变组织P16、Ki67表达及临床意义

Expression and Clinical Significance of P16 and Ki67 in Cervical Intraepithelial Neoplasia

目的:探讨宫颈上皮内瘤变(CIN)组织中P16、Ki67的表达及其与CIN病变分级的相关性。方法:选取2018年1月-2020年1月病理科手术切除100例CIN患者的组织标本,检测其组织样本中P16、Ki67表达情况,比较CIN不同病变分级P16、Ki67表达情况及其相关性。结果:P16在CINⅠ级、Ⅱ级患者中阳性表达率分别为30.77%(20/65)、77.14%(27/35);Ki67在CINⅠ级、Ⅱ级患者中阳性表达率分别为20.00%(13/65)、77.14%(27/35)。CINⅠ级、Ⅱ级患者中P16、Ki67阳性表达率比较,差异均有统计学意义(P<0.05)。CINⅠ级中P16、Ki67多为阴性与弱阳性表达,分别为69.23%、80.77%;而CINⅡ级中P16、Ki67多为阳性或强阳性表达,均为77.14%。Spearman相关分析显示,P16、Ki67表达与宫颈病变程度均呈正相关性(r=0.653、0.692,P<0.05)。结论:CIN患者P16、Ki67在CINⅠ、Ⅱ级病变中均有不同程度表达,且P16、Ki67阳性表达与宫颈病变程度密切相关,可作为CIN临床病理分级参考依据。

Objective:To investigate the expression of P16 and of tissue samples Ki67 in cervical intraepithelial neoplasia(CIN)and their correlation with the grading of CIN.Method:A total of 100 patients of tissue samples with CIN in the Department of Pathology from January 2018 to January 2020 were selected,the expression of P16 and Ki67 were detected in their tissue samples,and the expression of P16 and Ki67 in different CIN lesion grades were compared and their correlation were analyzed.Result:The positive expression rate of P16 in CINⅠandⅡpatients were 30.77%(20/65)and 77.14%(27/35),respectively.The positive expression rates of Ki67 in CINⅠandⅡpatients were 20.00%(13/65)and 77.14%(27/35),respectively.The positive expression rates of P16 and Ki67 in CINⅠandⅡpatients were statistically significant(P<0.05).In CINⅠ,P16 and Ki67 were mostly negative and weakly positive,69.23%and 80.77%respectively.In CINⅡ,P16 and Ki67 were mostly positive or strongly positive,accounting for 77.14%.The expressions of P16 and Ki67 in CIN patients were positively correlated with CIN grades(r=0.653,0.692,P<0.05).Conclusion:In CIN patients,P16 and Ki67 were expressed to varying degrees in CINⅠandⅡlesions,and the positive expression of P16 and Ki67 was closely related to the degree of cervical lesions,which could be used as a reference for the clinicopathological grading of CIN.