蓝光光疗联合熊去氧胆酸对新生儿黄疸血清指标及疗效的影响

Effect of Blue Light Therapy Combined with Ursodeoxycholic Acid on Serum Index and Curative Effect of Neonatal Jaundice

目的:探究蓝光光疗联合熊去氧胆酸对新生儿黄疸血清指标及疗效的影响。方法:选取2020年2月-2021年2月本院收治的88例新生儿黄疸,按照随机数字表法将其分为联合组与蓝光组,每组44例。蓝光组实施蓝光光疗,联合组在对照组的基础上加用熊去氧胆酸治疗。比较两组疗效和不良反应发生情况;比较两组治疗前后的胆红素指标[总胆红素(TBIL)、间接胆红素(IBIL)、结合胆红素(DBIL)]及血清指标[超敏C反应蛋白(hs-CRP)、总胆汁酸(TBA)、γ-谷氨酰基转移酶(γ-GT)]。结果:联合组总有效率为97.73%,高于蓝光组的79.55%,差异有统计学意义(P<0.05)。治疗前,两组IBIL、DBIL、TBIL、hs-CRP、γ-GT、TBA水平比较,差异均无统计学意义(P>0.05);治疗后,两组IBIL、DBIL、TBIL、hs-CRP、γ-GT、TBA水平均低于治疗前,且联合组均低于蓝光组,差异均有统计学意义(P<0.05)。联合组不良发生率为18.18%,低于蓝光组的22.73%,差异无统计学意义(P>0.05)。结论:蓝光光疗联合熊去氧胆酸能有效治疗新生儿黄疸,不良反应少,血气指标改善明显,安全可靠。

Objective:To explore the efficacy of blue light therapy combined with Ursodeoxycholic Acid on serum index and curative effect of neonatal jaundice.Method:A total of 88 children with neonatal jaundice admitted to our hospital from February 2020 to February 2021 were selected,and they were divided into combined group and blue light group according to random number table method,44 cases in each group.The blue light group was treated with blue light therapy,and the combined group was treated with Ursodeoxycholic Acid on the basis of the control group.The efficacy and adverse reactions were compared between two groups;the bilirubin indexes[total bilirubin (TBIL),indirect bilirubin (IBIL),conjugated bilirubin (DBIL)]and serum indexes[hs-CRP,total bile acid (TBA),γ-glutamyltransferase (γ-GT)]before and after treatment were compared between two groups.Result:The total effective rate of the combined group was 97.73%,which was higher than 79.55% of the blue light group,the difference was statistically significant (P<0.05).Before treatment,there were no significant differences in the levels of IBIL,DBIL,TBIL,hs-CRP,γ-GT and TBA between two groups (P>0.05);after treatment,the levels of IBIL,DBIL,TBIL,hs-CRP,γ-GT and TBA of both groups were lower than those before treatment,and those of the combination group were lower than those of the blue light group,the differences were statistically significant (P<0.05).The incidence of adverse events in the combined group was 18.18%,which was lower than 22.73% of the blue light group,the difference was not statistically significant (P>0.05).Conclusion:Blue light therapy combined with Ursodeoxycholic Acid can effectively treat neonatal jaundice,with less adverse reactions,obvious improvement of blood gas index,safety and reliability.