雌激素对冠心病炎症进展的影响

Estrogen effects on the inflammatory progression of coronary heart disease

流行病学调查发现,女性冠心病(CHD)患者的平均发病年龄比男性晚10~15年,女性绝经前CHD的发病率是男性的1/10~3/10,但绝经后发病率却显著升高,这一发现提示冠心病的发生及进展存在明显的性别差异,其主要原因可能是女性雌激素水平发生的变化。CHD是一种由多因素参与共同作用的慢性炎症性疾病,其炎症贯穿了整个疾病的发生及发展过程,并最终决定了疾病的转归。本文将就雌激素对冠心病炎症进展的影响做一综述。

Epidemiological investigations found that the average age of onset of coronary heart disease(CHD)in women is 10-15 years later than that of men. The incidence of CHD in women before menopause is 1/10~3/10 of that in men,however,the incidence after menopause has increased significantly.This finding suggests that there is a significant gender difference in the occurrence and progression of CHD.The main reason may be related to the changes in female estrogen levels. CHD is a chronic inflammatory disease involving multiple factors. The effect of the inflammation runs through the entire process of disease occurrence and development,and ultimately determines the outcome of the disease. This article reviews the influence of estrogen on the progression of CHD inflammation.