Acsl4、Topo Ⅱ α在浸润性乳腺癌组织中表达与HER2、PR及ER的关系

Association of Acsl4,Topo Ⅱ α expression and HER2,PR and ER in invasive breast cancer tissues

目的探讨Acsl4、Topo Ⅱα在浸润性乳腺癌组织中的表达与HER2、PR、ER的关系。方法收集本院2019年4月至2021年5月期间行乳腺癌改良根治术患者的病理标本126例作为观察组,另选同期因良性病变手术切除的乳腺组织标本42例作为对照组,免疫组化法检测Acsl4、Topo Ⅱα的表达,并分析其表达与HER2、PR、ER的关系。结果观察组的Acsl4、Topo Ⅱα两者阳性表达显著高于对照组,差异有统计学意义(P<0.05)。HER2阳性的Acsl4、Topo Ⅱα阳性表达均高于HER2阴性,而PR、ER阴性的Acsl4、Topo Ⅱα表达均高于PR、ER阳性,差异均有统计学意义(P<0.05)。高分化肿瘤的Acsl4、Topo Ⅱα阳性表达高于中分化、低分化,差异有统计学意义(P<0.05);TNM分期为Ⅲ~Ⅳ期的Acsl4、Topo Ⅱα阳性表达高于Ⅰ~Ⅱ期;肿瘤直径>5 cm的Acsl4、Topo Ⅱα阳性表达高于肿瘤直径<2cm、肿瘤直径2~5 cm;淋巴结转移的Acsl4、Topo Ⅱα阳性表达高于未转移;差异均有统计学意义(P<0.05)。Acsl4、Topo Ⅱα表达与年龄、是否绝经比较,差异无统计学意义(P>0.05)。结论 Acsl4、Topo Ⅱα在乳腺癌组织中存在异常表达,两者的阳性表达与乳腺癌患者组织学分级、淋巴结转移、肿瘤直径、及ER阴性、PR阴性、HER2阳性的表达密切相关。

Objective To explore the relationship of Acsl4,Topo Ⅱ α expression and HER2,PR,ER in invasive breast cancer tissues. Methods Pathological specimens of 126 patients with modified radical breast cancer between April 2019 and May 2021 were collected as observation groups,and 42 breast tissue specimens surgical removed from benign lesions were selected as control groups. Acsl4,TopoⅡα expression was detected by immunohistochemistry and the relationship between expression and HER2,PR,ER was analyzed. Results The positive expression of both Acsl4 and TopoⅡα was significantly higher in the observed group than in the control group;HER2 positive Acsl4,TopoⅡα positive expression were higher than HER2 negative,However,Acsl4 and TopoⅡα expression negative for PR and ER were higher than positive for PR and ER;The positive expression of Acsl4 and TopoⅡα in highly differentiated tumors was higher than in moderately differentiated and poorly differentiated tumors;The positive expression of Acsl4 and TopoⅡ α with TNM stage was higher than stage Ⅰ~Ⅱ;Positive expression of Acsl4 and TopoⅡα with a tumor diameter of>5 cm was higher than the tumor diameter of <2 cm and 2~5 cm in tumor diameter;The positive expression of Acsl4 and TopoⅡα in lymph node metastasis was higher than that of not in metastasis;The differences were all statistically significant(P<0.05). Acsl4,TopoⅡα expression and age,and menopause were not significant(P>0.05). Conclusion Aberrant expression of Acsl4,TopoⅡα in breast cancer tissues,and positive expres-sion of both was closely correlated with histological grade,lymph node metastasis,tumor diameter,and ER negative,PR negative,and HER2 positive expression in breast cancer patients.