艾迪与顺铂胸腔灌注联合静脉应用培美曲塞二钠治疗肺腺癌合并恶性胸腔积液的效果

Effect of Addie and Cisplatin Combined with Intravenous Pemetrexed Disodium in the Treatment of Lung Adenocarcinoma Complicated with Malignant Pleural Effusion

目的将艾迪与顺铂胸腔灌注联合静脉应用培美曲塞二钠用于肺腺癌合并恶性胸腔积液的临床治疗,研究并分析其临床治疗效果。方法以2020年4月至2021年4月这一区间作为研究时段,在这一期间从合理选择我院收治的肺腺癌合并恶性胸腔积液患者64例进行研究分析,按照患者入院先后顺序进行分组,前50%入院患者计为本次研究对照组,后50%入院患者组成本次研究试验组,每组分别包括32例患者。两组患者均给予静脉应用培美曲塞二钠治疗,并在此前提下,对照组患者进行顺铂胸腔灌注,试验组实施艾迪与顺铂胸腔灌注,治疗完成后,观察并分析两组临床疗效。结果对比两组临床疗效发现,试验组患者的临床治疗总有效率明显高于对照组(P<0.05);并且试验组的不良反应发生率远远低于对照组(P<0.05)。结论对于肺腺癌合并恶性胸腔积液患者进行艾迪与顺铂胸腔灌注联合静脉应用培美曲塞二钠治疗具有非常显著的临床治疗效果,能够有效改善患者病情症状,降低不良反应发生概率,促进患者身体功能以及各项生理指标恢复,具有较高的临床应用价值。

Objective To study and analyze the clinical therapeutic effects of addie and cisplatin combined with intravenous pemetrexed disodium in the treatment of lung adenocarcinoma complicated with malignant pleural effusion.Methods In April 2020 to April 2021 the interval as the research time,during this period from the rational selection of lung adenocarcinoma with our hospital to study and analysis of 64 patients with malignant pleural effusion,grouping order according to the patients admitted to hospital,the top 50%hospitalized patients in the control group in this study,50%of hospitalized patients in this study,each group included 32 patients.Both groups were given intravenous pemetrexed disodium treatment,and on this premise,patients in the control group were given cisplatin pleural infusion,while patients in the experimental group were given addie and cisplatin pleural infusion.After completion of treatment,the clinical efficacy of the two groups was observed and analyzed.Results Comparing the clinical efficacy of the two groups,it was found that the total effective rate of the experimental group was significantly higher than that of the control group(P<0.05).The incidence of adverse reactions in the experimental group was much lower than that in the control group(P<0.05).Conclusion For lung adenocarcinoma with malignant pleural effusion patients with addie and cisplatin pleural perfusion combined intravenous application of pemetrexed disodium treatment has very significant clinical effect,can effectively improve the symptoms of patients,reduce the adverse reaction probability,promote patients body function and each physiological index,has high clinical value.