蛋白质组学在阿尔茨海默病中的应用研究进展

Advances in the application of proteomics in Alzheimer’s disease

阿尔茨海默病(Alzheimer’s disease,AD)是一种多发于老年人群的中枢神经系统退行性疾病,其患病率和发病程度与年龄呈正相关。蛋白质组学是一门以生物体或细胞蛋白质为研究对象的新兴学科,已成为当前生命科学研究的热点与前沿。本文就目前蛋白质组学应用于AD研究的现状作一综述,尤其对蛋白质组学技术在探究AD发病机理,从脑脊液、血液、尿液中寻找生物标志物和发现药物靶点等方面进行了回顾,以期为AD的早期诊断和治疗提供新思路。

Alzheimer’s disease(AD)is a degenerative disease of the central nervous system that often occurs in the elderly and its prevalence and severity are positively correlated with age.Proteomics is an emerging branch with biological or cellular proteins as the research object and has become the current hotspot and research frontier of life science.This paper reviews the current status of the application of proteomics in AD research,especially in exploring the pathogenesis of AD,looking for biomarkers from cerebrospinal fluid,blood and urine,and discovering drug targets,which provide new ideas for early diagnosis and treatment of AD.