线粒体自噬在干细胞中的作用及其机制研究进展

Research advances in the role and mechanism of mitophagy in stem cells

线粒体自噬是一种选择性的自噬形式,能选择性清除功能异常或多余的线粒体,以维持其质量及功能稳定,被视为细胞稳态的一种重要调节形式。干细胞是一类具有自我更新、多能性及分化潜能的细胞,在个体发育、组织更新及某些疾病过程中均起着至关重要的作用。研究显示,线粒体自噬与干细胞自我更新、多能性及分化密切相关。该文综述了线粒体自噬在多种正常干细胞(胚胎干细胞、诱导性多能干细胞、造血干细胞、间充质干细胞、神经干细胞、心脏干细胞)及肿瘤干细胞中的作用及其调控机制,旨在深入理解线粒体自噬与干细胞生物学特征的关系,为进一步研究干细胞的调控机制及治疗策略提供参考。

Mitophagy is a selective form of autophagy that can selectively remove abnormal or redundant mitochondria to maintain the quality and function of mitochondria,so is regarded as an important regulation form of cell homeostasis.Stem cells are a type of cells with self-renewal,pluripotency and differentiation potential,and play a vital role in individual development,tissue renewal and certain diseases.Studies have shown that mitophagy is highly correlated with the self-renewal,pluripotency and differentiation of stem cells.The function and regulation mechanism of mitophagy in a variety of normal stem cells(embryonic stem cells,induced pluripotent stem cells,hematopoietic stem cells,mesenchymal stem cells,neural stem cells,cardiac stem cells)and cancer stem cells have been reviewed in present paper,so is to deeply understand the relationship between mitophagy and the biological functions of stem cells,and to provide a new theoretical reference for stem cell regulatory mechanisms and treatment strategies.