摘要
A light-promoted metal-free protocol for the amination of imidazo[1,2-a]pyridines with N-aminopyridinium salt by the assistance of surfactants in water was reported,charactering mild and environmentally benign conditions,as well as great functional group tolerance.Micelles with negatively charged polar surface and hydrophobic core formed from sodium dodecyl sulfate serve as an ideal medium for visible-light mediated radical reaction of cationic pyridine salt and imidazo[1,2-a]pyridine in aqueous phase.The electrostatic interaction between positively charged N-aminopyridinium and negatively charged surface of micelles is of great significance in this method.
基金
We thank the National Natural Science Foundation of China(Grant Nos.21901216 and 21871031)
the Fund of Science and Technology Agency of Chengdu(2019-YF09-00049-SN)
the Open Project Program of Irradiation Preservation Technology Key Laboratory of Sichuan Province,Sichuan Institute of Atomic Energy(No.FZBC2020002)
the Sichuan Science and Technology Program(2020YFH0061,2020YJ0222,2021JDRC0018,2021YFS0092,2021YFSY0041,2021YFH0064).