超声联合Ki-67在乳腺癌新辅助化疗疗效评价中的应用价值

Application Value of Ultrasound Combined with Ki-67 in Evaluation of Curative Effect of Neoadjuvant Chemotherapy for Breast Cancer

目的探讨超声联合Ki-67在乳腺癌新辅助化疗(NACT)疗效评价中的应用价值.方法选取行NACT的乳腺癌患者45例,分别于NACT周期前、后行超声检查;患者入院后行组织穿刺活检术,获取免疫组化Her-2基因扩增情况,并对超声及Ki-67数据进行统计分析.结果NACT前后患者病灶直径、面积、Ki-67变化比较差异具有统计学意义(P<0.01);影像学评估、Ki-67变化及二者联合评估均与病理学分级具有相关性.结论超声联合Ki-67能更好地评估NACT疗效,可为患者个体化治疗提供依据.

Objective To investigate the application value of ultrasound combined with Ki-67 in neoadjuvant chemotherapy(NACT)of breast cancer.Method 45 cases of breast cancer patients with NACT were selected to perform ultrasound examination before and after all cycles of NACT;The immunohistochemical results of Her-2 gene amplification were obtained.The data of ultrasound and Ki-67 were statistically analyzed.Results The size,area and Ki-67 of lesions before and after NACT were significantly changed(P<0.01);Imaging evaluation,Ki-67 changes and their combined evaluation were correlated with pathological grading evaluation.Conclusion Ultrasound combined with Ki-67 can evaluate the efficacy of NACT.