摘要
目的探讨肾间质炎症在顽固性高血压患者肾功能损伤中的作用。方法选取2016年6月至2018年12月在该院诊治的顽固性高血压肾病患者85例作为研究组,另选取同期单纯顽固性高血压患者60例作为对照组。检测两组患者的肾间质炎症相关指标及肾功能,同时分析肾间质炎症相关指标与顽固性高血压肾病患者肾功能的相关性。结果与对照组比较,研究组患者24 h尿蛋白定量、肌酐、尿素氮增高,差异均有统计学意义(P<0.05)。与对照组患者比较,研究组患者尿白细胞介素(IL)-18、尿IL-1β增高,差异均有统计学意义(P<0.05)。顽固性高血压肾病患者尿IL-18、IL-1β与24 h尿蛋白定量、肌酐、尿素氮均呈正相关(P<0.05)。结论肾间质炎性反应参与了顽固性高血压肾病的发生,炎性指标尿IL-18、IL-1β可以作为新的临床监测指标,为顽固性高血压的治疗提供参考依据,值得进一步研究。
Objective To investigate the role of renal interstitial inflammation in renal function damage in patients with refractory hypertension.Methods From June 2016 to December 2018,85 patients with refractory hypertension with nephropathy in a hospital were selected as the study group, and 60 patients with simple refractory hypertension in the same period were selected as the control group.The renal interstitial inflammation related indicators and renal function of the two groups were detected, and the correlation between renal interstitial inflammation related indicators and renal function of refractory hypertensive nephropathy patients was analyzed.Results Compared with the control group, 24 h urinary protein, creatinine, urea nitrogen increased in the study group, the differences were statistically significant(P<0.05).Compared with control group, urinary interleukin(IL)-18 and urinary IL-1β were increased in study group, the difference was statistically significant(P<0.05).Urine IL-18 and IL-1β were positively correlated with 24 h urine protein, creatinine and urea nitrogen in patients with refractory hypertensive nephropathy(P<0.05).Conclusion Renal interstitial inflammatory reaction is involved in the occurrence of refractory hypertensive nephropathy.Urinary IL-18 and IL-1β,inflammatory indicators, can be used as new clinical monitoring indicators to provide reference for the treatment of refractory hypertension, which is worthy of further study.
作者
夏燕平
臧秀娟
XIA Yanping;ZANG Xiujuan(Department of Nephrology,Songjiang District Central Hospital,Shanghai 201600,China)
出处
《检验医学与临床》
CAS
2022年第1期13-15,共3页
Laboratory Medicine and Clinic
基金
上海市松江区科委课题项目(10SJGG24)。
关键词
肾间质炎症
顽固性高血压
肾功能
renal interstitial inflammation
intractable hypertension
renal function