高尿酸血症治疗的研究进展

Research progress on treatment of hyperuricemia

高尿酸血症是由于体内嘌呤代谢紊乱导致的代谢性疾病。我国高尿酸血症患病率高达13.3%。高尿酸血症不仅是痛风最重要的危险因素,也与多个重要靶器官损害密切相关。目前临床上使用的降尿酸药物存在一定的副作用且大多治疗成本较高。营养素是维持人体基本功能必不可少的物质。研究发现,叶酸、维生素C、血清磷、血清镁等营养素与高尿酸血症发生风险呈负相关,提示营养治疗可能是防治高尿酸血症的潜在策略。本文对高尿酸血症的发病机制、并发症及治疗进展进行综述。

Hyperuricemia is a metabolic disease caused by a disorder of purine metabolism.The prevalence of hyperuricemia is about 13.3%in Chinese adults.Hyperuricemia is not only the most important risk factor for gout,but also closely associated with target organs damage.The uric acid-lowering drugs currently used in clinical practice have certain side effects and most of them are costly to treat.Nutrients are essential for the maintenance of basic body functions.Studies have found that nutrients such as folic acid,vitamin C,serum phosphorus,and se‐rum magnesium are negatively associated with the risk of hyperuricemia,suggesting that nutritional therapy may be a potential strategy to prevent and treat hyperuricemia.This article provides a review of the pathogenesis,com‐plications,and treatment advances of hyperuricemia.