Phactr1与多血管疾病的研究进展:从基础到临床

Advances in Phactr1 related polyvascular disease:from bench to bedside

最近的全基因组关联研究发现并确认Phactr1是一个与多种血管疾病相关的风险基因。但是,Phactr1如何调控血管疾病的发生发展尚不明确。近年来的研究表明:Phactr1编码了一种能与肌动蛋白和蛋白磷酸酶1结合的蛋白,可以调节内皮细胞的增殖、凋亡、迁移和管形成,影响巨噬细胞的极化,以及血管平滑肌细胞的钙化。本文围绕Phactr1与多血管疾病的相关性及Phactr1调控动脉粥样硬化的分子机制,阐述Phactr1在多血管疾病进程中的作用和治疗潜力。

Recent genome-wide association studies have identified Phactr1 as a risk gene associated with polyvascular diseases.However,it remains elusive how Phactr1 is involved in the pathogenesis of vascular diseases.More recently,mounting evidence has suggested that PHACTR1 as an actin and protein phosphatase 1 binding protein,regulates endothelial proliferation,apoptosis,migration and tube formation,affects polarization in macrophages,and aggravates calcification in vascular smooth muscle cells.This paper focuses on the correlation between Phactr1 and polyvascular disease,and the molecular mechanism of Phactr1 in regulating atherosclerosis.We thus provided an overview of the role and therapeutic potential of Phactr1 in the progression of polyvascular disease.