PM_(2.5)对动脉粥样硬化的影响及机制

The effect of fine particulate matter on atherosclerosis and its mechanism

细颗粒物(PM_(2.5))不仅能直接损伤肺组织,还可经肺泡毛细血管吸收进入血液,对心血管系统产生毒害作用。PM_(2.5)可通过诱导氧化应激、炎症反应、自主神经功能紊乱和免疫调节异常等机制影响血脂代谢、内皮功能,促凝血和血栓形成,对动脉粥样硬化(AS)有明显促进作用,易导致斑块不稳定,增加心血管疾病的发病率和死亡率。本文对国内外关于PM_(2.5)对AS的影响及机制研究进行综述,为预防空气污染导致的心血管疾病研究提供依据。

Fine particulate matter(PM_(2.5))not only directly damages lung tissue,but also can be absorbed into blood through alveolar capillaries,which is toxic to the cardiovascular system.PM_(2.5)can affect lipid metabolism,endothelial function,coagulation and thrombosis through oxidative stress,inflammatory reaction,autonomic nervous dysfunction and immune regulation abnormality,so that it promote arteriosclerosis,plaque instability,and increase the morbidity and mortality of cardiovascular disease.We reviewed the effects and mechanisms of PM_(2.5)on arteriosclerosis,in order to provide the evidence for the studies into prevention of cardiovascular diseases caused by air pollution.