泄泻中医证候动物模型研究进展

Research progress on animal model construction and evaluation of different TCM syndromes of diarrhea

泄泻是中医常见疾病,中医辩证治疗常常取得较好疗效。中医证候动物模型的建立对于中医研究具有重大意义,科学简便的动物模型建立方法有利于中医的发展,目前不同的泄泻证型尚无各自统一公认的中医证候模型建立标准。对泄泻肠道湿热证、寒湿困脾证、食滞脾胃证、肝郁脾虚证、脾气亏虚证、脾肾阳虚证动物模型制作方法进行综述,发现目前的泄泻动物模型具有造模方法混乱、造模因素选择随机、模型评价标准主观等问题,并提出模型改进建议,以期建立行业认可、简便高效、科学稳定的泄泻中医症候模型。

Diarrhea is a common disease in traditional Chinese medicine(TCM), and dialectical treatment with TCM often achieves better result. Establishing animal models of TCM syndromes is of great significance to TCM research. Simple animal model establishment method are conducive to the development of TCM. At present, there is no uniformly recognized standard for establishing TCM syndrome models of diarrhea. The author of this article reviewed the method for generating animal models of diarrhea, including intestinal dampness-heat syndrome, cold-dampness trapping the spleen syndrome, stagnation of spleen and stomach syndrome, liver depression and spleen deficiency syndrome, spleen-qi deficiency syndrome and spleen-kidney yang deficiency syndrome, and found that the current approaches are unclear because of the random selection of modeling factors, subjective model evaluation criteria and other issues. This review provides suggestions for model improvement to establish industry-recognized, simple, efficient, scientific and stable diarrhea TCM syndrome models.