基于祛风理气活血基础方的中西医结合治疗白癜风的临床疗效分析

Efficacy of integrated Chinese and Western medicine in the treatment of vitiligo based on the basic formula of Qufeng Liqi Huoxue

目的:观察基于祛风理气活血的中药基础方联合常规西药治疗白癜风的有效性、安全性及临床可行性,为在西医综合型医院推广中西医病症结合治疗白癜风提供依据。方法:将218例白癜风患者分为病例组126例(采用中药基础方联合常规西药治疗),对照组92例(采用单纯西药治疗)。比较两组疗效、白斑消退率、不良反应,并分层分析。结果:病例组总有效率62.70%(79/126),对照组总有效率41.30%(38/92),两组差异有统计学意义(P=0.001)。病例组白斑消退率为(38.62±19.11)%,对照组为(20.94±19.51)%,两组差异有统计学意义(P<0.001)。分层分析显示,病例组进展期和稳定期总有效率和白斑消退率均高于对照组(P<0.05)。两组系统应用糖皮质激素患者的总有效率和白斑消退率差异无统计学意义。病例组不良反应发生率为7.14%,对照组为6.52%,两组差异无统计学意义。不良反应均以胃肠道反应为主,能耐受。结论:中药基础方联合常规西药治疗白癜风疗效肯定、安全性良好、可行性强,值得临床推广。

Objective:To assess the efficacy,safety,and clinical feasibility of traditional Chinese medicine formula,based on Qufeng Liqi Huoxue,combined with conventional Western medicine in the treatment of vitiligo,so as to provide a basis for the promotion of this therapeutic strategy.Methods:A total of 218 patients with vitiligo were divided into 2 groups,of which 126 were treated by traditional Chinese medicine basic formula combined with conventional Western medicine orally(case group),and 92 treated only with conventional Western medicine(control group).The efficiency,leukoplakia regression rates,and adverse effects between the two groups were compared,and stratification analysis was performed.Results:The total efficiency rate of 62.70%(79/126)in the case group was higher than that in the control group(41.30%,38/92;P=0.001).The rate of leukoplakia regression of(38.62±19.11)%in the case group was higher than that in the control group([20.94±19.51]%,P<0.001).Stratification analysis showed that the rates of the total efficiency and leukoplakia regression both in the progressive and stable stages in the case group were higher than those in the control group(P<0.05).But in the patients using glucocorticoid,there was no significant difference in the total efficiency and the rate of leukoplakia regression between the two groups.The adverse effect rate was 7.14%in the case group and 6.52%in the control group,and there was also no significant difference between the two groups.The adverse effects were mainly gastrointestinal effects and could be tolerated.Conclusions:For the treatment of vitiligo,oral traditional Chinese medicine formula combined with conventional Western medicine has definite curative effect,good safety,and strong feasibility,and is worthy of clinical promotion.