慢性阻塞性肺疾病患者血浆Clara细胞分泌蛋白水平的变化及其与动脉血气的相关性

Changes of plasma Clara cell secretory protein level and its relationship with arterial blood gas in patients with chronic obstructive pulmonary disease

目的:探讨慢性阻塞性肺疾病(chronic obstructive pulmonary disease,COPD)患者血浆Clara细胞分泌蛋白(Clara cell secretory protein,CC16)水平变化及其与动脉血气的关系。方法:回顾性分析2019年3月至2020年6月上海市宝山区仁和医院收治的94例COPD患者和43例健康者的临床资料,分为COPD稳定期组(n=49)、COPD急性加重期组(n=45)和健康组(n=43)。对比3组血浆CC16水平和动脉血气相关参数[动脉血氧pH值、动脉血氧分压(PaO_(2))、动脉血二氧化碳分压(PaCO_(2))、动脉血氧饱和度(SaO_(2))]水平。采用Pearson相关分析探讨COPD患者血浆CC16水平与动脉血气相关参数的相关性。结果:健康组血浆CC16、pH、PaO_(2)、SaO_(2)水平高于稳定期组,稳定期组高于急性加重期组,差异均有统计学意义(P<0.05);稳定期组、急性加重期组PaCO_(2)明显高于健康组,且急性加重期组明显高于稳定期组(P<0.05);COPD稳定期(r=0.752、0.824、0.874)、急性加重期(r=0.768、0.856、0.917)、所有COPD患者(r=0.759、0.839、0.887)血浆CC16水平与pH、PaO_(2)及SaO_(2)水平均正相关,与PaCO_(2)则均负相关(r=-0.819、-0.835、-0.820),P均<0.05。结论:稳定期、急性加重期COPD患者血浆CC16水平与动脉血气相关参数相关,且COPD急性加重期患者变化幅度均明显大于COPD稳定期。

Objective:To explore the changes of plasma Clara cell secretory protein(CC16)and its relationship with arterial blood gas in patients with chronic obstructive pulmonary disease(COPD).Methods:The clinical data of 94 COPD patients and 43 healthy people admitted to the Renhe Hospital of Baoshan District in Shanghai from March 2019 to June 2020 were retrospectively analyzed.Study subjects were divided into stable COPD group(n=49),acute exacerbation COPD group(n=45),and healthy group(n=43).The levels of plasma CC16 and arterial blood gas related parameters(arterial oxygen pH,arterial partial pressure of oxygen[PaO_(2)],arterial partial pressure of carbon dioxide[PaCO_(2)],arterial oxygen saturation[SaO_(2)])were compared among the three groups.Pearson correlation analysis was used to explore the correlation between the changes of plasma CC16 levels and arterial blood gas related parameters in COPD patients.Results:The levels of plasma CC16,pH,PaO_(2) and SaO_(2) in the healthy group were higher than those in the stable COPD group,and which in the stable COPD group were higher than those in the acute exacerbation COPD group,with statistically significant differences(P<0.05).The PaCO_(2) in the stable COPD group and the acute exacerbation COPD group were higher than that in the healthy group,and which in the acute exacerbation COPD group was higher than that in the stable COPD group(P<0.05).The levels of plasma CC16 were positively correlated with pH,PaO_(2),and SaO_(2) in the stable COPD group(r=0.752,0.824,0.874),the acute exacerbation COPD group(r=0.768,0.856,0.917),and COPD patients(r=0.759,0.839,0.887),whereas negatively correlated with PaCO_(2)(r=-0.819,-0.835,-0.820),all P<0.05.Conclusions:There are correlations between plasma CC16 levels and arterial blood gas parameters in stable and acute exacerbation COPD patients,and the changes in acute exacerbation COPD patients are significantly greater than those in stable COPD patients.