摘要
副溶血性弧菌是水产品中主要的致病菌之一,既可造成养殖水产品的疾病与死亡,也可引起人类的胃肠炎等疾病,不仅具有潜在的食品安全隐患,也对消费者健康造成潜在危害。该文主要阐述了副溶血性弧菌的毒力因子耐热直接溶血素(thermostable direct hemolysin,TDH)以及分泌系统T3SS1、T3SS2在菌株体内的作用机理,并对副溶血性弧菌产生耐药性的5种机制——产生生物被膜、质粒介导耐药、产生灭活酶或钝化酶类、外排泵主动排出抗菌药物、药物靶点发生改变进行了综述。
Vibrio parahaemolyticus is one of the main pathogenic bacteria in aquatic products.It can cause diseases and deaths of aquaculture products,as well as gastroenteritis and other diseases in humans.It not only has potential food safety hazards,but also poses potential hazards to human health.This article mainly describes the virulence factor tdh ofⅤ.parahaemolyticus and the mechanism of the typeⅢsecretion system(T3 SS),T3 SS1 and T3 SS2 in the strains,and five mechanisms ofⅤ.parahaemolyticus resistance to drugs were reviewed:production of biofilm,plasmid mediated drug resistance,the production of inactivated or inactivated enzymes,the efflux pump,and the change of drug targets.
作者
张健
朱秋华
张明
王丽卫
董浩
曾仙童
白梧桐
郭晓华
申照华
宋钢
张德福
励建荣
ZHANG Jian;ZHU Qiuhua;ZHANG Ming;WANG Liwei;DONG Hao;ZENG Xiantong;BAI Wutong;GUO Xiaohua;SHEN Zhaohua;SONG Gang;ZHANG Defu;LI Jianrong(College of Food Science and Technology,Institute of Ocean,Bohai University,Food Safety Key Lab of Liaoning Province,National and Local Joint Engineering Research Center of Storage,Processing and Safety Control Technology for Fresh Agricultural and Aquatic Products,Jinzhou 121013,China;State Key Laboratory of Biochemical Engineering,Institute of Process Engineering,Chinese Academy of Sciences,Beijing 100190,China;Shandong Meijia Group Co.Ltd.,Rizhao 276806,China;Jinzhou Longhaixingang Science and Technology Co.Ltd.,Jinzhou 121211,China;Linghai Dalian Seafood Process Co.Ltd.,Jinzhou 121211,China)
出处
《食品与发酵工业》
CAS
CSCD
北大核心
2022年第1期301-307,共7页
Food and Fermentation Industries
基金
国家重点研发计划项目(2019YFD0901702)
国家自然科学基金项目(31801662)。
关键词
副溶血性弧菌
耐热直接溶血素
T3SS
耐药机制
质粒
Vibrio parahaemolyticus
thermoslable direct hemolysin(TDH)
T3SS
mechanism of drug resistance
plasmid
