谷氨酰胺代谢在肺纤维化疾病中的研究进展

Research progress on glutamine metabolism in pulmonary fibrosis

肺纤维化是一种进展迅速的肺部疾病,以成纤维细胞增殖及大量细胞外基质沉积、肺组织结构破坏为特征的间质性肺疾病。其中位生存期为3-4年。目前治疗方法有限,预后较差。最近在器官纤维化中发现了多种代谢异常,其中包括谷氨酰胺代谢异常。文章主要就谷氨酰胺代谢过程在促进肺纤维化发病过程中的作用研究进展进行综述。

Pulmonary fibrosis is a rapidly progressive lung disease characterized by fibroblast proliferation,massive extracellular matrix deposition and destruction of lung tissue,with limited treatments and poor prognosis.Its median survival was 3 to 4 years.A variety of metabolic abnormalities,such as glutamine metabolism abnormalities,have recently been identified in organ fibrosis.This review discusses how glutamine metabolic processes promote the pathogenesis of pulmonary fibrosis.