老年高血压患者应用尿常规检验中常用四项指标的价值探讨

Discussion on the value of applying four common indicators of urine routine test in elderly patients with hypertension

目的探讨老年高血压患者应用尿常规检验中常用四项指标的价值。方法60例老年高血压患者,根据病程的不同分为A组、B组及C组,各20例。所有患者均开展尿常规检验。对比三组患者24 h尿蛋白定量、尿微量白蛋白、尿β2微球蛋白及N-乙酰-β-D-氨基葡萄糖苷酶水平,不同分级高血压患者尿常规检测结果及尿胆红素、尿糖、尿胆原及尿酮体阳性率。结果C组24 h尿蛋白定量(0.58±0.07)g/24 h、尿微量白蛋白(66.42±0.87)mg/L、尿β2微球蛋白(889.56±30.54)μg/L及N-乙酰-β-D-氨基葡萄糖苷酶(17.33±2.27)U/L均高于A组的(0.22±0.01)g/24 h、(8.87±0.92)mg/L、(145.67±50.13)μg/L、(12.52±1.24)U/L及B组的(0.45±0.06)g/24 h、(30.53±0.29)mg/L、(482.36±21.23)μg/L、(13.49±1.38)U/L,且B组高于A组,差异具有统计学意义(P<0.05)。高血压3级患者24 h尿蛋白定量、尿微量白蛋白、尿β2微球蛋白及N-乙酰-β-D-氨基葡萄糖苷酶水平均高于高血压1级和2级患者,且高血压2级患者高于高血压1级患者,差异有统计学意义(P<0.05)。不同分级高血压患者尿胆红素、尿糖、尿胆原及尿酮体阳性率对比,差异有统计学意义(P<0.05)。结论尿常规检验中常用四项指标与老年高血压患者的病程及病情变化均有着密切的关系。

Objective To discuss the value of applying four common indicators of urine routine test in elderly patients with hypertension.Methods 60 elderly patients with hypertension were divided into group A,group B and group C according to their courses of the disease,with 20 cases in each group.Urine routine test was carried out in all patients.The 24-h urinary protein quantification and levels of urinary microalbumin,urinaryβ2 microglobulin and N-acetyl-β-D-glucosaminidase of the three groups were compared.Further,urine routine test results and positive rates of urinary bilirubin,urine glucose,urobilinogen and urinary ketone in patients with different grades of hypertension were also compared.Results In group C,the 24-h urinary protein quantification was(0.58±0.07)g/24 h,the urine microalbumin was(66.42±0.87)mg/L,the urineβ2 microglobulin was(889.56±30.54)μg/L and N-acetyl-β-D glucosaminidase was(17.33±2.27)U/L,which were higher than those of group A[(0.22±0.01)g/24 h,(8.87±0.92)mg/L,(145.67±50.13)μg/L,(12.52±1.24)U/L]and group B[(0.45±0.06)g/24 h,(30.53±0.29)mg/L,(482.36±21.23)μg/L,(13.49±1.38)U/L],and group B was higher than group A.All differences were statistically significant(P<0.05).The 24-h urinary protein quantification and levels of urinary microalbumin,urinaryβ2 microglobulin and N-acetyl-β-D-glucosaminidase of patients with grade 3 hypertension were higher than those of patients with grade 1 hypertension,and the differences were statistically significant(P<0.05).Differences in the positive rates of urinary bilirubin,urine glucose,urobilinogen and urinary ketone of patients with different grades of hypertension were statistically significant(P<0.05).Conclusion In practice,four indicators are commonly used in a urine routine test.These indicators are closely related to the course of disease and the change of disease condition.