甲泼尼龙联合羟基脲治疗原发性膜性肾病的临床效果

Clinical effect of methylprednisolone combined with hydroxycarbamide in the treatment of primary membranous nephropathy

目的探讨分析甲泼尼龙联合羟基脲治疗原发性膜性肾病的临床效果。方法200例原发性膜性肾病患者,按随机数字法分为对比组和观察组,每组100例。对比组口服甲泼尼龙治疗,观察组在对比组治疗基础上联合口服羟基脲治疗。比较两组治疗效果、24 h尿蛋白沉淀定量、血肌酐、血清白蛋白、并发症发生情况。结果观察组治疗总有效率96%高于对比组的80%,差异有统计学意义(P<0.05)。对比组的24 h尿蛋白沉淀定量为(1.25±0.83)g/24 h、血肌酐为(97.91±11.41)μmol/L、血清白蛋白为(28.41±5.92)g/L;观察组的24 h尿蛋白沉淀定量为(0.91±0.79)g/24 h、血肌酐为(84.61±10.21)μmol/L、血清白蛋白为(34.61±4.31)g/L。观察组24 h尿蛋白沉淀定量、血肌酐均低于对比组,血清白蛋白高于对比组,差异均有统计学意义(P<0.05)。观察组并发症发生率与对比组比较,差异无统计学意义(P>0.05)。结论甲泼尼龙联合羟基脲治疗原发性膜性肾病的临床效果更好,值得进行临床应用。

Objective To discuss and analyze the clinical effect of methylprednisolone combined with hydroxycarbamide in the treatment of primary membranous nephropathy.Methods A total of 200 patients with primary membranous nephropathy were divided into comparison group and observation group according to the random numerical table,with 100 cases in each group.The control group was treated with oral methylprednisolone,and the observation group was treated with oral hydroxycarbamide on the basis of the control group.The therapeutic effect,24 h urinary protein quantification,blood creatinine,serum albumin,and complications were compared between the two groups.Results The total effective rate of treatment 96%in the observation group was higher than 80%of the control group,and the difference was statistically significant(P<0.05).In the control group,the 24 h urinary protein quantification was(1.25±0.83)g/24 h,the serum creatinine was(97.91±11.41)μmol/L,and the serum albumin value was(28.41±5.92)g/L;in the observation group,the 24-h urinary protein quantification was(0.91±0.79)g/24 h,the serum creatinine was(84.61±10.21)μmol/L,and the serum albumin was(34.61±4.31)g/L.The 24-h urinary protein quantification and serum creatinine of the observation group were lower than those of the control group,and the serum albumin was higher than that of the control group.All the differences were statistically significant(P<0.05).There was no statistically significant difference in the complication rates between the observation group and the control group(P>0.05).Conclusion Methylprednisolone combined with hydroxycarbamide has significant clinical effect on the treatment of primary membranous nephropathy,and it is worthy of clinical application.