固体药物多晶型的研究进展

Research Progress on Polymorphs of Solid Medicines

药物多晶型的研发一直是生物制药领域的研究热点,药物的不同晶态会对药品溶解度、溶出速率、生物利用率等各方面产生重要影响。它也是药品生产质量安全控制中一项关键的环节。它为药物研究提供了一个全新的发展思路。通过梳理、分析和总结近20年来国内外关于药物多晶型的相关文献,介绍了药物多晶型的研究意义、制备方法及其对临床应用的影响。

The research and development of drug polymorphs has always been a research hotspot in the field of biopharmaceuticals.The different crystal states of drugs will have an important impact on drug solubility,dissolution rate,bioavailability and other aspects;it is also one of the quality and safety control of drug production It provides a brand-new development idea for drug research.By combing,analyzing and summarizing the relevant literatures on drug polymorphs at home and abroad in the past 20 years,this article introduces the research significance,preparation methods and their impact on clinical applications of drug polymorphs.