循环微RNA生物标志物应用于子宫内膜异位症诊断的现状和挑战

Research Status and Challenge of Application of Circulating MicroRNA as Diagnostic Biomarkers of Endometriosis

子宫内膜异位症好发于生育活跃期患者,其发病率高、病变广泛。因腹腔镜操作受限,子宫内膜异位症的临床诊断常具有延迟性,导致患者错失最佳诊治时机,所以迫切需要寻找一种非侵入性、高特异性和敏感性的诊断方法。微RNA(miRNA/miR)是生物体内重要的转录后调控因子,可参与多种疾病的发生发展过程,具有敏感性高、不易降解等特点,极易在组织中被检出。在子宫内膜异位症患者的血液中,miR-125b、miR-17、miR-122、miR-199a和miR-200家族表达水平明显升高,且与子宫内膜异位症发病具有相关性,有望成为诊断子宫内膜异位症的生物标志物。

Endometriosis occurs more frequently in reproductive-age women,and is characterized by high incidence and extensive lesions.Due to laparoscopic operation restrictions,the clinical diagnosis of endometriosis is often delayed,resulting in missing the best time for treatment.Therefore,it is urgent to find a non-invasive,highly specific and sensitive diagnostic method.MicroRNA(miRNA/miR)is a type of important post-transcriptional regulator in organisms and is involved in the occurrence and development of various diseases,which has high sensitivity and is not easy to be degraded,making it very easy to be detected in tissues.The expressions of miR-125b,miR-17,miR-122,miR-199a and miR-200 families in the blood of endometriosis patients are significantly increased and correlated with the onset of endometriosis,which are expected to be biomarkers for the diagnosis of endometriosis.