糖尿病相关认知功能障碍发病机制研究进展

Research Progress of Pathogenesis of Diabetes Mellitus Associated Cognitive Dysfunction

随着糖尿病患病率的不断升高,糖尿病相关认知功能障碍已成为糖尿病常见且重要的并发症之一,严重影响患者的生活质量。糖尿病相关认知功能障碍的发病机制复杂,主要包括脑血管和血脑屏障损伤、β淀粉样蛋白沉积、tau蛋白过度磷酸化、胰岛素抵抗、神经炎症、脑神经元损伤以及代谢异常等。多种因素共同作用促进糖尿病相关认知功能障碍的发生发展,目前临床尚缺乏有效预防和治疗措施。因此,充分探讨糖尿病认知功能障碍的发病机制,并积极探寻新的作用靶点,有助于降低或延缓糖尿病相关认知功能障碍的发生发展。

With the increasing prevalence of diabetes mellitus,its associated cognitive dysfunction has become one of the common and important complications,which seriously affects the quality of life of the patients.The pathogenesis of diabetes mellitus-associated cognitive dysfunction is complex,mainly including cerebrovascular and blood-brain barrier injury,β-amyloid deposition,tau protein hyperphosphorylation,insulin resistance,neuroinflammation,brain neuron damage and metabolic abnormalities.Multiple factors contribute to the development of diabetes mellitus-associated cognitive dysfunction,and there are still no effective preventive and therapeutic measures at present.Therefore,fully exploring the pathogenesis of diabetes mellitus-associated cognitive dysfunction and actively exploring new targets can help to reduce or delay the occurrence and development of diabetes mellitus-associated cognitive dysfunction.