神经节苷脂治疗病毒性脑炎患者的效果

Effects of Gangliosides on patients with viral encephalitis

目的:观察神经节苷脂治疗病毒性脑炎患者的效果。方法:选取80例病毒性脑炎患者为研究对象,按照随机数字表法分为观察组与对照组各40例。对照组给予常规治疗,观察组在对照组基础上采用神经节苷脂治疗,比较两组临床疗效、神经功能指标[神经元特异性烯醇化酶(NSE)、中枢神经特异性蛋白(S100β)、髓鞘碱性蛋白(MBP)]水平、症状缓解时间(意识好转、呕吐消失、抽搐消失、脑膜刺激征消失、退热时间)和不良反应发生率。结果:观察组治疗总有效率为97.50%,明显高于对照组的75.00%,差异有统计学意义(P<0.05);治疗后,两组NSE、S100β、MBP水平均低于治疗前,且观察组明显低于对照组,差异有统计学意义(P<0.05);观察组意识好转、呕吐消失、抽搐消失、脑膜刺激征消失和退热时间均短于对照组,差异有统计学意义(P<0.05);治疗期间,两组均未出现明显不良反应。结论:在常规治疗基础上采用神经节苷脂治疗可提高病毒性脑炎患者治疗总有效率,缩短症状缓解时间,以及改善神经功能指标水平,效果优于单纯常规治疗。

Objective:To observe effects of Gangliosides on patients with viral encephalitis.Methods:80 patients with viral encephalitis were selected as the research objects,and were divided into observation group and control group according to the random number table method,40 cases in each group.The control group was given conventional treatment,while the observation group was treated with Gangliosides on the basis of that of the control group.The clinical efficacy,the nerve function index levels[neuron-specific enolase(NSE),central nervous system-specific protein(S100β),serum myelin basic protein(MBP)],the symptom relief time(improvement of consciousness,disappearance of vomiting,disappearance of convulsions,disappearance of meningeal irritation sing,fever clearance time)and the incidence of adverse reactions were compared between the two groups.Results:The total effective rate of treatment in the observation group was 97.50%,which was significantly higher than 75.00%in the control group,and the difference was statistically significant(P<0.05).After the treatment,the levels of NSE,S100βand MBP in the two groups were lower than those before the treatment;those of the observation group were significantly lower than those of the control group;and the differences were statistically significant(P<0.05).The time of improvement of consciousness,disappearance of vomiting,disappearance of convulsions,disappearance of meningeal irritation sing,fever clearance of the observation group were significantly shorter than those of the control group;and the differences were statistically significant(P<0.05).During the treatment period,there were no obvious adverse reactions in the two groups.Conclusions:On the basis of conventional treatment,the use of Ganglioside therapy can increase the total effective rate of treatment of the patients with viral encephalitis,shorten the time of symptom relief,and improve the levels of nerve function indicators.Moreover,it is superior to single conventional treatment.