全身化疗联合调强放射治疗对复发性晚期三阴性乳腺癌的疗效分析

Effects of systemic chemotherapy combined with intensity modulated radiation therapy on recurrent triple negative breast carcinoma

目的探讨全身化疗联合调强放射治疗对复发性晚期三阴性乳腺癌(TNBC)的疗效。方法采用回顾性研究方法,选择122例在我院诊治的复发性晚期TNBC患者作为研究对象,根据治疗方法的不同分为观察组(62例)与对照组(60例)。对照组给予全身化疗治疗,观察组在对照组的基础上联合调强放射治疗。比较两组患者的疗效、毒副反应、免疫功能以及预后。结果观察组患者治疗总有效率显著高于对照组(67.7%vs.33.3%,P<0.05)。两组患者治疗期间骨髓抑制、消化道反应、脱发等毒副反应发生率比较,差异均无统计学意义(P>0.05)。观察组患者治疗后CD3^(+)、CD4^(+)水平显著高于治疗前,并显著高于对照组(P<0.05),而对照组治疗前后CD3^(+)、CD4^(+)水平比较,差异无统计学意义(P>0.05)。观察组患者总生存期及无进展生存期均显著长于对照组(P<0.05)。结论全身化疗联合调强放射治疗可提高复发性晚期TNBC患者的疗效,改善其免疫功能,延长其总生存期及无进展生存期,且不增加毒副反应。

Objective To investigate the effects of systemic chemotherapy combined with intensity modulated radiation therapy in the treatment of recurrent advanced triple negative breast carcinoma(TNBC).Methods A total of 122 patients with recurrent advanced TNBC in our hospital were selected and were divided into the observation group(n=62)and the control group(n=60)according to their different treatment methods.The control group was given the systemic chemotherapy treatment,and the observation group was given the systemic chemotherapy combined with intensity modulated radiation therapy.Compare the efficiency,the incidence of adverse reaction,the immune function and the prognosis of patients between the two groups.Results The total effective rate of the observation group was significantly higher than that of the control group(67.7%vs.33.3%,P<0.05).There were no significant differences in the incidence of bone marrow suppression,digestive tract reaction,and alopecia between the two groups during treatment(P>0.05).The levels of CD3^(+)and CD4^(+)in the observation group after treatment were significantly higher than those before treatment,and were also significantly higher than those in the control group(P<0.05).However,no significant differences were observed in the levels of CD3^(+)and CD4^(+)before and after treatment in the control group(P>0.05).The overall survival and progression-free survival in the observation group were significantly longer than those in the control group(P<0.05).Conclusion For recurrent advanced TNBC patients,the systemic chemotherapy combined with intensity modulated radiation therapy improved the therapeutic effect and the immune function,and prolonged the total survival period and the progression-free survival period of the patients.It yet did not increase the incidence of side effects.