猪肺磷脂注射液气管灌洗治疗胎粪吸入综合征患儿的效果

Effects of Poractant Alfa injection tracheal lavage in children with meconium aspiration syndrome

目的:观察猪肺磷脂注射液气管灌洗治疗胎粪吸入综合征(MAS)患儿的效果。方法:选取60例MAS患儿为研究对象,按照随机数字表法分为研究组与对照组各30例。对照组予以常规治疗,研究组在对照组基础上予以猪肺磷脂注射液气管灌洗治疗,比较两组动脉血氧分压(PaO_(2))、氧合指数(PaO_(2)/FiO_(2))、白细胞介素(IL)-6、IL-8、高敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)水平及不良反应发生率。结果:治疗24 h后,两组PaO_(2)、PaO_(2)/FiO_(2)水平均高于治疗前,且研究组明显高于对照组,差异有统计学意义(P<0.05);治疗24 h后,两组IL-6、IL-8、hs-CRP和TNF-α水平均低于治疗前,且研究组明显低于对照组,差异有统计学意义(P<0.05);两组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:在常规治疗基础上给予猪肺磷脂注射液气管灌洗治疗可提高MAS患儿PaO_(2)、PaO_(2)/FiO_(2)水平,降低IL-6、IL-8、hs-CRP和TNF-α水平,效果优于单纯常规治疗。

Objective:To observe effects of Poractant Alfa injection tracheal lavage in children with meconium aspiration syndrome(MAS).Methods:60 children with MAS were selected as the research objects,and were divided into study group and control group according to the random number table method,30 cases in each group.The control group was given conventional treatment,while the study group was given Poractant Alfa injection tracheal lavage on the basis of that of the control group.The arterial partial pressure of oxygen(PaO_(2))level,the oxygenation index(PaO_(2)/FiO_(2))level,the levels of interleukin-6(IL)-6,IL-8,high-sensitivity C-reactive protein(hs-CRP),tumor necrosis factor-α(TNF-α)and the incidence of adverse reactions were compared between the two groups.Results:After 24 hours of treatment,the levels of PaO_(2) and PaO_(2)/FiO_(2) in the two groups were higher than those before the treatment;those of the study group were significantly higher than those of the control group;and the differences were statistically significant(P<0.05).After 24 hours of treatment,the levels of IL-6,The levels of IL-8,hs-CRP and TNF-αwere lower than those before the treatment;those of the study group were significantly lower than those of the control group;and the differences were statistically significant(P<0.05).However,there was no statistically significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusions:On the basis of the conventional treatment,Poractant Alfa injection tracheal lavage can increase the PaO_(2) and PaO_(2)/FiO_(2) levels,and reduce the IL-6,IL-8,hs-CRP and TNF-αlevels in the children with MAS.Moreover,it is superior to single conventional treatment.