血清免疫球蛋白、可溶性致癌抑制因子2与类风湿关节炎活动度的相关性

Correlations among serum immunoglobulin,soluble oncogenic suppressor 2 levels and rheumatoid arthritis activity

目的:探讨血清免疫球蛋白(Ig)、可溶性致癌抑制因子2(sST2)与类风湿关节炎(RA)活动度的相关性。方法:选取300例RA患者作为研究对象,根据RA病情活动度评价表(DAS28)评估其不同活动度(高活动度、中活动度、低活动度、疾病稳定),并检测其IgG、IgA、IgM、sST2水平,比较不同活动度RA患者的血清IgG、IgA、IgM、sST2水平,并采用Kendall’s tau-b直线相关检验分析RA患者血清IgG、IgA、IgM、sST2水平与RA活动度的关系。结果:300例RA患者中,DAS28评分<2.6分65例(疾病稳定),占21.67%(65/300);2.6分≤DAS28评分<3.2分107例(低活动度),占35.67%(107/300);3.2分≤DAS28评分≤5.1分94例(中活动度),占31.33%(94/300);DAS28评分>5.1分34例(高活动度),占11.33%(34/300)。高活动度RA患者血清IgG、IgA、IgM、sST2水平均高于中活动度、低活动度、疾病稳定患者;中活动度RA患者血清IgG、IgA、IgM、sST2水平均高于低活动度、疾病稳定患者;低活动度RA患者血清IgG、IgA、IgM、sST2水平均高于疾病稳定患者,差异有统计学意义(P<0.05)。一般线性双变量Kendall’s tau-b直线相关检验结果显示,血清IgG、IgA、IgM、sST2水平与RA活动度呈正相关(r>0,P<0.05)。结论:血清IgG、IgA、IgM、sST2水平与RA活动度呈正相关。

Objective:To explore correlations among serum immunoglobulin(Ig),soluble oncogenic suppressor 2(sST2)levels and rheumatoid arthritis(RA)activity.Methods:300 RA patients were selected as the research objects.The disease activity was assessed by using RA disease activity evaluation form(DAS28)(high activity,medium activity,low activity,stable disease).The IgG,IgA,IgM,sST2 levels were detected.The serum IgG,IgA,IgM,sST2 levels of the RA patients with different activities were compared.Kendall’s tau-b linear correlation test was used to analyze the relationship among the serum IgG,IgA,IgM,sST2 levels and RA activities in these patients.Results:Among the 300 RA patients,65 patients had DAS28 score<2.6(stable disease),accounting for 21.67%(65/300);107 patients with 2.6≤DAS28 score<3.2(low activity),accounting for 35.67%(107/300));94 patients with 3.2≤DAS28 score≤5.1(medium activity),accounting for 31.33%(94/300);34 cases with DAS28 score>5.1 points in(high activity),accounting for 11.33%(34/300).The serum IgG,IgA,IgM,and sST2 levels in the patients with high activity RA were higher than those with moderate activity,low activity,and stable disease;the serum IgG,IgA,IgM,and sST2 levels in the patients with moderate activity RA were higher than those with low activity and stable disease;the serum IgG,IgA,IgM,and sST2 levels in the patients with low activity RA were higher than those with stable disease;and the differences were statistically significant(P<0.05).General linear bivariate Kendall’s tau-b linear correlation test showed that the serum IgG,IgA,IgM,sST2 levels were positively correlated with RA activity(r>0,P<0.05).Conclusions:The serum IgG,IgA,IgM,sST2 levels are positively correlated with RA activity.