替格瑞洛与氯吡格雷对PCI治疗不稳定型心绞痛患者的血液流变学指标及不良反应影响

Effect of ticagrelor and clopidogrel on hemorheological indexes and adverse reactions in unstable angina patients with PCI

目的探究替格瑞洛与氯吡格雷对经皮冠状动脉介入术(PCI)治疗不稳定型心绞痛患者血小板的抑制作用。方法选取本院2018年11月至2019年8月收治的62例行PCI治疗的不稳定型心绞痛患者,按照入院顺序尾数的单双数分为替格瑞洛组和氯吡格雷组,每组31例。替格瑞洛组给予替格瑞洛治疗,氯吡格雷组给予氯吡格雷治疗。比较两组血小板抑制作用、血液流变学指标及不良反应发生率。结果治疗后30 d,替格瑞洛组IPA高于氯吡格雷组,BV高切、BV低切、PV水平均低于氯吡格雷组(P<0.05);替格瑞洛组不良反应发生率低于氯吡格雷组(P<0.05)。结论与氯吡格雷相比,替格瑞洛对PCI治疗不稳定型心绞痛患者血小板抑制作用更理想,用药后可在较短时间迅速抑制血小板聚集,改善机体血流状态,且不良反应发生率低,用药安全性高,值得临床推广应用。

Objective To investigate the effect of ticagrelor and clopidogrel on platelet suppression in unstable angina patients with percutaneous coronary intervention(PCI).Methods 62 cases of unstable angina patients with PCI who were treated in our hospital from November 2018 to August 2019 were selected,and they were divided into the ticagrelor group and the clopidogrel group according to the single and double numbers of the order of admission,with 31 cases in each group.Ticagrelor group was treated with ticagrelor and clopidogrel group was treated with clopidogrel.The platelet inhibition,hemorheological index and adverse reaction rate were compared between the two groups.Results 30 days after treatment,the IPA in Ticagrelor group was higher than that in Clopidogrel group,the levels of BV,BV and PV were lower than in clopidogrel group(P<0.05);The incidence of adverse reactions in the ticagrelor group was lower than that in the clopidogrel group(P<0.05).Conclusion Compared with clopidogrel,ticagrelor can inhibit platelet aggregation quickly after administration,and improve blood flow in patients,and the adverse reactions is low and the safety is high,it is worth popularizing.