探讨阻塞性睡眠呼吸暂停低通气综合征与肺栓塞的病理机制及预后策略

Explore the Pathological Mechanism and Prognostic Strategy of Obstructive Sleep Apnea Hypopnea Syndrome and Pulmonary Embolism

目的:探讨阻塞性睡眠呼吸暂停低通气综合征(OSAHS)与肺栓塞(PE)的病理机制、预后策略以及临床特点。方法:选取2019年6月至2020年6月黑龙江省第三医院呼吸内科收治的OSAHS合并PE的患者60例作为观察组,另外选取同期的OSAHS未合并PE的患者60例作为对照组,分析2组临床治疗效果。结果:1)观察组吸烟指数及体质量指数(BMI)显著高于对照组,动脉血氧分压(PaO_(2))显著低于对照组,2组比较差异有统计学意义(均P<0.05);2)对照组治疗有效率为93.33%,观察组患者治疗有效率为95.00%,2组患者治疗有效率比较,差异无统计学意义(P>0.05)。结论:合并OSAHS的PE患者年龄偏低,病情较为严重,对于这些患者需要为其开展CPAP呼吸机联合抗凝治疗,用以缓解患者的病情。

Objective:To investigate the pathological mechanism,prognostic strategy and clinical characteristics of Obstructive Sleep Apnea Hypopnea Syndrome(OSAHS)and Pulmonary Embolism(PE).Methods:A total of 60 patients with OSAHS complicated with PE treated in The Department of Respiratory Medicine of the Third Hospital of Heilongjiang Province from June 2019 to June 2020 were selected as the observation group,and another 60 patients with OSAHS during the same period were selected as the control group to analyze the clinical treatment effect of the two groups.Results:1)The smoking index and body mass index(BMI)of the observation group were significantly higher than those of the control group,while arterial partial pressure of Oxygen(PaO_(2))was significantly lower than that of the control group.The differences between the two groups were statistically significant(Ps<0.05);2)The effective rate of the control group was 93.33%,and that of the observation group was 95.00%.There was no significant difference in the effective rate between the two groups(P>0.05).Conclusion:PE patients combined with OSAHS are younger and the conditions are more serious.For these patients,a CPAP ventilator combined with anticoagulant therapy is needed to alleviate their condition.