组蛋白去乙酰化酶对缺血性脑卒中病理过程调控的研究进展

Research progress of histone deacetylases in regulating the pathological process of ischemic stroke

组蛋白去乙酰化酶(histone deacetylases,HDACs)是一类蛋白酶,通过调节组蛋白和非组蛋白翻译后修饰,对染色体的结构修饰和基因表达调控发挥着重要的作用。通常情况下,HDACs对神经系统的发育、成熟和损伤修复中具有重要的作用。由于HDACs在细胞质和细胞核中的分布不同,因此在脑缺血的相关机制中表现出不同的作用。HDACs根据序列、结构和功能同源性分为四个类别和18种亚型。本文就HDACs各个亚型在缺血性脑卒中后神经细胞中的定位及作用进行综述。

Histone deacetylases (HDACs) are proteases that play an important role in chromosome structural modification and gene expression regulation by modulating histone and non-histone post-translational modifications.Typically,HDACs participate in the development,maturation,and injury repair of the nervous system.HDACs exhibit various functions in related mechanisms of cerebral ischemia according to their distribution in cytoplasm and nuclei.Recent studies classify HDACs into four classes with 18 subtypes based on sequence,structural and functional homology.This review discusses the localization and function of each HDACs subtype in neurocytes after ischemic stroke.