阿培利西的合成路线图解

Graphical Synthetic Routes of Alpelisib

阿培利西是一种新型磷脂酰肌醇-3-激酶α(PI3K-α)抑制剂,用于治疗绝经后女性及男性晚期或转移性的乳腺癌患者。文章对阿培利西已有的2条合成路线进行分析总结,2条路线各有优劣,可通过优化或改进,探索新的工艺路线,为该药物的进一步研发提供参考。

Alpelisib is a new inhibitor of phosphatidylinositol-3-kinaseα(PI3K-α)used for treating postmenopausal females and males with advanced or metastatic breast cancer.This paper analyzes and summarizes the two existing synthetic routes of Alpelisib.Each of the two routes has its advantages and disadvantages.New process routes can be explored through optimization or improvement to provide a reference for the further research and development of the drug.