面向我国化学物质环境管理的计算毒理学模型评估思路及建设路径

Evaluation Thoughts of Computational Toxicological Models and Constructional Path for Environmental Management of Chemicals in China

计算毒理学模型正逐渐成为我国化学物质环境管理的重要工具之一。为了推动建立面向我国化学物质环境管理的计算毒理学模型评估方法体系,掌握模型评估核心技术,本文分析了我国发展和评估计算毒理学模型的必要性,总结了我国计算毒理学模型评估的管理需求,系统梳理了美国、欧盟、国际经济合作与发展组织(OECD)的模型评估方法。研究发现,发达国家普遍建立了一套相对完善的计算毒理学模型评估技术,构建了包含模型开发、评估、验证和应用的模型生命周期评估体系。当前,我国尚未建立计算毒理学模型评估技术方法,借鉴发达国家的经验做法,构建具有我国国情特征的计算毒理学模型评估体系,指导我国计算毒理学模型征集与评估工作,具有重要意义。

Computational toxicological models are gradually becoming one of the most important tools for chemical environmental management in China.In order to promote the establishment of the evaluation method system of computational toxicology models for chemical environmental management in China and master the core technology of model evaluation,this paper analyzed the necessity of developing and evaluating computational toxicology models,summarized the management requirements of computational toxicology model evaluation in China,and systematically reviewed the model evaluation methods of the United States,the European Union and the Organization for Economic Co-operation and Development(OECD).It was found that in developed countries,a set of relatively perfect computational toxicology model assessment technology had been established,and a model life cycle assessment system including model development,assessment,validation and application had been constructed.At present,computational toxicology model evaluation techniques of China has not been established.It is of great significance to build a computational toxicology model evaluation system based on the experience of developed countries,and to guide the collection and evaluation of computational toxicology models in China.